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ProteomicsMitochondrial E3 ubiquitin ligase MARCHF5 controls BAK function independently of BH3-only proteins
Intrinsic apoptosis is principally regulated by the BCL-2 family of proteins, but some non-BCL-2 proteins also serve as important regulators. To identify novel apoptosis regulators, we performed a genome-wide CRISPR-Cas9 library screen, and it identified the mitochondrial E3 ubiquitin ligase MARCHF5...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-25 | PXD030246 | Pride
Apoptosis  bak  bcl-2  marchf5/mitol  e3 ubiquitin ligase  mitochondria  bh3 mimetic 
TranscriptomicsMitol dysfunction triggers apoptosis of hematopoietic stem cell via ER stress response
Cellular metabolism exceedingly determines hematopoietic stem cells (HSCs) divisional fate and functioning through organelles interaction upon stress-induced response. The outer mitochondrial membrane-localized E3 ubiquitin ligase Mitol/Marchf5 (encoded by Mitol gene) is known to regulate mitochondr...
ORGANISM(S): Mus musculus 
2023-12-18 | GSE240788 | GEO
UnknownMitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins.
Not available
S-EPMC9984372 | biostudies-literature
GenomicsMitol dysfunction triggers apoptosis of hematopoietic stem cell via ER stress response
Mitol dysfunction triggers apoptosis of hematopoietic stem cell via ER stress response
PRJNA1005246 | ENA
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