Sort   by:  
 Page size 
ProteomicsApplication of SWATH Mass Spectrometry and Machine Learning in Diagnosis of Inflammatory Bowel Disease Based on Stool Proteome
Our hypothesis was that conducting proteomic analysis on clinical laboratory samples which are intended for the fecal calprotectin test would enable the develop-ment of a highly sensitive and specific non-invasive stool test based on mass spec-trometry. To investigate this hypothesis, we combined an...
ORGANISM(S): Homo sapiens (Human) 
2024-02-01 | PXD047585 | Pride
Human Inflammatory bowel disease. Stool 
UnknownYeast Ribonucleotide Reductase Is a Direct Target of the Proteasome and Provides Hyper Resistance to the Carcinogen 4-NQO.
Not available
S-EPMC10057556 | biostudies-literature
ProteomicsProteomics analysis of human breast milk by two-dimensional polyacrylamide gel electrophoressi (2D-PAGE) coupled with mass spectrometry to assess breast cancer risk
Breast Cancer (BC) is one of the most common cancers and one of the most common causes for cancer- related mortality. Discovery of protein biomarkers associated with cancer, is considered as important for early diagnosis and prediction of the cancer risk. Protein biomarkers could be investigated by ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-20 | PXD040188 | Pride
Breast cancer  breast milk  biomarkers  protein dysregulation  2d-page  proteomics  mass spec-trometry 
ProteomicseXL-MS: An enhanced Cross-Linking Mass Spectrometry Workflow to Study Protein Complexes.
The analysis of proteins and protein complexes by cross-linking mass spectrometry (XL-MS) has expanded in the last dec-ade. However, mostly used approaches suffer important limitations in term of efficiency and sensitivity. We describe here a new workflow based on the advanced use of the trifunction...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2021-08-11 | PXD010422 | Pride
Creatine kinase Mass spectrometry Cross-link Monoavidin biotin affinty enrichment Click chemistry 
ProteomicsPeptide centric detection of cross-linked peptides using PASEF, MeroX, and Skyline
Cross-linking mass spectrometry (XL-MS) has evolved into a pivotal technique for probing protein interactions, with recent ad-vancements significantly enhancing its analytical potential. This technical note presents advancements in cross-linking mass spec-trometry (XL-MS) through the implementation ...
ORGANISM(S): Bos Taurus 
PXD047307 | panorama
ProteomicsA zwitterionic detergent and catalyst-based single-cell proteomics using a loss-free microhole-collection disc
Recent advances in single-cell proteomics have solved many bottlenecks, such as throughput, sample recovery, and scalability via nano-scale sample handling. In this study, we aimed for a sensitive mass spectrometry analysis capable of handling single cells with a conventional mass spectrometry workf...
ORGANISM(S): Homo sapiens (Human) 
2025-05-28 | PXD048052 | Pride
Zwitterionic detergent Tandem mass tags Quadrol Single-cell proteomics 
ProteomicsIn-vivo crosslinking based affinity purification-mass spectrometry for targeting intracellular protein-protein interactions
Comprehensive interactome analysis of targeted proteins is of great significance to understand how pro-teins work together for functional regulation. Until now, affinity purification strategy with mass spec-trometry (AP-MS) has been recognized as the most widely used technique for studying protein-p...
ORGANISM(S): Homo Sapiens 
2022-12-01 | PXD038473 |
ProteomicsHotspot DNMT3A and IDH1/2 Mutations in Acute Myeloid Leukemia and Their Relevance as Targets for Immunotherapy
DNA methyltransferase 3A (DNMT3A) and isocitrate dehydrogenase 1 & 2 (IDH1/2) are genes involved in epigenetic regulation, each mutated in 7-23% of acute myeloid leukemia (AML). Here, we investigated whether hotspot mutations in these genes encode neoantigens that can be targeted by immunotherapy. F...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050560 | Pride
Hotspot mutation Iso-citrate dehydrogenase 2 Dna methyltransferase 3a Cancer immunotherapy Acute myeloid leukemia Neoantigen T-cell therapy 
GenomicsIntegrated gut microbiome andserum lipidomics revealsmicrobial-lipid interactions forpredicting incident metabolicsyndrome
Integrated gut microbiome andserum lipidomics revealsmicrobial-lipid interactions forpredicting incident metabolicsyndrome
PRJEB122826 | ENA
ProteomicsComparative analysis of laboratory-scale IgG purification methods from human serum
Immunoglobulin G (IgG) purification is a critical process for evaluating its role in autoimmune diseases, which are defined by the occurrence of autoantibodies. Affinity chromatography with protein G is widely considered the optimal technique for laboratory-scale purification. However, this techniqu...
ORGANISM(S): Homo sapiens (Human) 
2024-09-02 | PXD050732 | Pride
Human serum Proteomics Immunoglobulins g 
Sort   by:  
 Page size