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TranscriptomicsRNA CLIP-seq for Cugbp1, Mbnl1 and Ptbp1 in mouse C2C12 myoblasts
CUG-binding protein 1 (CUGBP1) and muscleblind-like 1 (MBNL1) are developmentally regulated RNA-binding proteins that are causally associated with myotonic dystrophy type 1. We extensively determined RNA-binding sites of CUGBP1 and MBNL1 to investigate their roles in RNA processing. We also analyzed...
ORGANISM(S): Mus musculus 
2012-01-04 | E-MTAB-414 | biostudies-arrayexpress
TranscriptomicsExon array analysis in the mouse myoblast cell line, C2C12 cells treated with control-, Cugbp1- or Mbnl1-siRNA
CUGBP1 and MBNL1 are developmentally regulated RNA-binding proteins that are causally associated with myotonic dystrophy type 1. Using HITS-CLIP anlysis, we found CUGBP1 and MBNL1 preferentially bind to alternatively spliced introns and exons, as well as to the 3' UTRs. To analyze more directly the...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-29990 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse expressing toxic UGexp RNA vs. Mbnl1 knockout and Clcn1 null mice to assess the post-transcriptional impact of toxic RNA in myotonic dystrophy
Myotonic dystrophy type 1 (DM1) is an RNA dominant disease in which mutant transcripts containing an expanded CUG repeat (CUGexp) cause muscle dysfunction by interfering with biogenesis of other mRNAs. The toxic effects of mutant RNA are mediated partly through sequestration of splicing regulator Mu...
ORGANISM(S): Mus musculus 
2009-02-13 | E-GEOD-14691 | biostudies-arrayexpress
GenomicsMBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
PRJNA508759 | ENA
UnknownAutoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.
Not available
S-EPMC5389549 | biostudies-literature
UnknownMBNL1-RNA recognition: contributions of MBNL1 sequence and RNA conformation.
Not available
S-EPMC3890438 | biostudies-literature
GenomicsRNA CLIP-seq for Cugbp1, Mbnl1 and Ptbp1 in mouse C2C12 myoblasts
RNA CLIP-seq for Cugbp1, Mbnl1 and Ptbp1 in mouse C2C12 myoblasts
PRJEB2614 | ENA
GenomicsThe RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1 [RNA-seq]
The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1 [RNA-seq]
PRJNA541923 | ENA
GenomicsMBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states [RIP-seq]
MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states [RIP-seq]
PRJNA1034546 | ENA
GenomicsMBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states [RNA-seq]
MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states [RNA-seq]
PRJNA1034545 | ENA
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