Sort   by:  
 Page size 
TranscriptomicsT-cell intracellular antigen (TIA) proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy
Background: Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1-related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for these proteins during embryonic development. However, intrinsic molecular and cellular consequences of either TIA1 or...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-43077 | biostudies-arrayexpress
TranscriptomicsmicroRNA and mRNA expression profiles of human embryonic stem cells treated with activin A
Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self-renewal and pluripotency enable hES cells having the potential to provide an unlimited suppl...
ORGANISM(S): Homo sapiens 
2010-09-10 | E-GEOD-16910 | biostudies-arrayexpress
TranscriptomicsRNA-chip from MEF cells
Genome wide chromatin maps have shown that spreading repressive histone modifications such as H3K9me3 and H4K20me3 are present on pericentromeric and telomeric repeats and on the inactive X chromosome where H3K27me3 or H3K9me3 alternately modify megabasepair sized domains. However, only a few region...
ORGANISM(S): Mus musculus 
2008-11-23 | E-GEOD-11337 | biostudies-arrayexpress
TranscriptomicsChip-chip from MEF cells with H3ac, H4ac, H4K20me1, H3K27me3, H3K9me3, H4K20me3, H3K4me2, H3K4me3 and H3K9ac
Genome wide chromatin maps have shown that spreading repressive histone modifications such as H3K9me3 and H4K20me3 are present on pericentromeric and telomeric repeats and on the inactive X chromosome where H3K27me3 or H3K9me3 alternately modify megabasepair sized domains. However, only a few region...
ORGANISM(S): Mus musculus 
2008-11-23 | E-GEOD-11335 | biostudies-arrayexpress
TranscriptomicsConnecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional regulators of ES cells has not been established. We describe here a new map of the transcriptional regulatory circuitr...
ORGANISM(S): Mus musculus 
2008-07-29 | E-GEOD-11724 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel imprinted genes by transcriptional analysis of parthenogenetic embryonic stem cells
Parthenogenetic embryonic stem cells (PESCs) may have future utility in cell replacement therapies. We examined genome-wide mRNA expression profiles of monkey PESCs relative to ESCs derived from fertilized embryos. Several known paternally-imprinted genes were in the highly down-regulated group in P...
ORGANISM(S): Macaca mulatta 
2010-07-07 | E-GEOD-17964 | biostudies-arrayexpress
TranscriptomicsImpaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal
Transcriptome profiling of three models with impaired insulin/IGF1 signaling. 1. Deep sequencing of endogenous mRNA from Caenorhabditis elegans N2 var. Bristol (wildtype) and daf-2(e1370) mutant; 2. Deep sequencing of endogenous mRNA from murine embryonic fibroblasts (MEF) wildtype and irs1-/- kno...
ORGANISM(S): Caenorhabditis elegans 
2012-02-25 | E-GEOD-36041 | biostudies-arrayexpress
ModelsHayashi2013 - TNF-induced Signaling Dynamics (Model A)
Hayashi2013 - TNF-induced Signaling Dynamics Model (Model A) Tumor necrosis factor (TNF) plays a crucial role in inflammation and is associated with diseases such as rheumatoid arthritis and cancer. While TNF signaling pathways are well studied, targeted regulation of proinflammatory responses rem...
2025-02-19 | MODEL2502170001 | BioModels
ModelsHayashi2013 - Extended TNF-induced Signaling with Gene Expression Dynamics (Model B)
Hayashi2013 - Extended TNF-induced Signaling with Gene Expression Dynamics (Model B) Tumor necrosis factor (TNF) plays a crucial role in inflammation and is associated with diseases such as rheumatoid arthritis and cancer. While TNF signaling pathways are well studied, targeted regulation of proin...
2025-02-19 | MODEL2502170002 | BioModels
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts (MEF) during adipocyte differentiation timeseries
Gene expression timeseries analysis of mouse embryonic fibroblasts (MEF) during differentiation to mature adipocytes with a 27.648 element murine cDNA microarray. Three independent time series experiments of MEF adipocyte differentiation were performed in reference design. RNA from 7 time points (0d...
ORGANISM(S): Mus musculus 
2010-01-20 | E-MARS-13 | biostudies-arrayexpress
Sort   by:  
 Page size