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TranscriptomicsThe transcription factor Amr1 induces melanin biosynthesis and suppresses virulence in Alternaria brassicicola
Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as virulence factors affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative ...
ORGANISM(S): Alternaria brassicicola 
2013-02-19 | E-GEOD-36781 | biostudies-arrayexpress
ProteomicsIntegrative Proteome and Metabolomics Analyses of Cryptococcus neoformans Responses to Melanin Substrates Niger seed and L-DOPA
Melanin, as a pivotal antioxidant pigment, plays a critical role in the pathogenicity of Cryptococcus neoformans. However, the underlying signaling pathways responsible for melanin biosynthesis in C. neoformans are not yet fully elucidated. In this study, proteome and metabolomics analyses were cond...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2025-07-23 | PXD056054 | Pride
Cryptococcus neoformans  melanin biosynthesis  substrate-dependent manner  substrate-independent manner 
TranscriptomicsCandida albicans DOPA-grown cells
The fungal pathogen Candida albicans produces dark-pigmented melanin when grown in a basal medium containing 1 mM l-DOPA as melanin substrate. In the widely used C. albicans strain SC5314, melanin appeared after 3-4 days of incubation in l-DOPA medium. The experiment was designed to reveal cadidat...
ORGANISM(S): Candida albicans 
2010-07-07 | E-GEOD-20338 | biostudies-arrayexpress
GenomicsUnravelling of the novel melanin biosynthesis-signalling networks in Cryptococcus neoformans
Unravelling of the novel melanin biosynthesis-signalling networks in Cryptococcus neoformans
PRJNA545271 | ENA
UnknownMelanin in fungi: advances in structure, biosynthesis, regulation, and metabolic engineering.
Not available
S-EPMC11657710 | biostudies-literature
TranscriptomicsUnravelling of the novel melanin biosynthesis-signalling networks in Cryptococcus neoformans
Melanin is an antioxidant polyphenol pigment, which is required for the pathogenicity of many human and plant fungal pathogens. Nevertheless, its comprehensive regulatory mechanism still remain elusive. In this study, we systematically analyzed melanin-regulating signaling pathways in Cryptococcus n...
ORGANISM(S): Cryptococcus neoformans H99 
2019-05-30 | GSE131891 | GEO
MetabolomicsDeletion of Gliotoxin Biosynthesis Remodels the Intra- and Extracellular Metabolic Status of Aspergillus fumigatus, Alters Its Virulence-Related Phenotypes, and Modulates Host Immune Responses_culture supernatant

Gliotoxin is a secondary metabolite produced by Aspergillus fumigatus, known to play a significant role in immune regulation and virulence phenotypes. This study investigates how the deletion of gliotoxin biosynthesis remodels the metabolic state of A. fumigatus and subsequently af...

2026-05-11 | MTBLS14011 | MetaboLights
TranscriptomicsThe transcription factor Amr1 induces melanin biosynthesis and suppresses virulence in Alternaria brassicicola
Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as virulence factors affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative tr...
ORGANISM(S): Alternaria brassicicola 
2013-02-19 | GSE36781 | GEO
UnknownLight-Triggered In Situ Biosynthesis of Artificial Melanin for Skin Protection.
Not available
S-EPMC8895148 | biostudies-literature
UnknownThe Verticillium dahliae Sho1-MAPK pathway regulates melanin biosynthesis and is required for cotton infection.
Not available
S-EPMC6916341 | biostudies-literature
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