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ProteomicsThe RNF185/Membralin ubiquitin ligase complex is a new ERAD branch involved in the degradation of a distinct subset of integral membrane proteins.
The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for ubiquitin-mediated quality control of secretory and ER-resident proteins. In the present study, two short-lived ER integral membrane model proteins were used to screen a genome-wide CRISPR-Cas9 library, resulting in t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-03 | PXD018517 | Pride
Endoplasmic reticulum-associated degradation (erad)  e3 ligase rnf185  membralin  tmem259  tmub1  tmub2  ubiquitin 
GenomicsMembralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment
PRJNA541312 | ENA
TranscriptomicsMembralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment
Mechanisms underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS) are yet unclear. Specific deletion of the ER-component membralin in astrocytes manifested postnatal motor defects and lethality in mice, causing the accumulation of extracellular glutamate through reducing the glu...
ORGANISM(S): Mus musculus 
2019-05-07 | GSE130763 | GEO
UnknownMembralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.
Not available
S-EPMC6668683 | biostudies-literature
UnknownThe critical role of membralin in postnatal motor neuron survival and disease.
Not available
S-EPMC4460860 | biostudies-literature
UnknownTapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression.
Not available
S-EPMC11445256 | biostudies-literature
UnknownMembralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.
Not available
S-EPMC12904022 | biostudies-literature
UnknownMembralin is required for maize development and defines a branch of the endoplasmic reticulum-associated degradation pathway in plants.
Not available
S-EPMC11194580 | biostudies-literature
UnknownQuality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.
Not available
S-EPMC7482433 | biostudies-literature
UnknownER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity.
Not available
S-EPMC5684335 | biostudies-literature
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