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MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
MetabolomicsCombined Mesenchymal Stem Cells and Metformin Therapy Modulates Key Macromolecular Pathways in Pulmonary Fibrosis: Evidence from Untargeted Metabolomics

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Current treatment options remain limited, driving interest in novel therapeutic approaches. Mesenchymal stem cells (MSCs) possess immunomodulatory and regenerative properties, while metformin, traditionally ...

2025-08-25 | MTBLS12893 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
MetabolomicsNon-destructive characterization of Mesenchymal stem cells
Not available
ORGANISM(S): Homo sapiens 
ST001981 | MetabolomicsWorkbench
MetabolomicsAMPK activation orchestrated replicative senescence of periodontal ligament stem cells via regulating metabolomics

BACKGROUND: Periodontal ligament mesenchymal stem cells (PDLSCs) are a promising cell resource for cell-based regenerative medicine in dentistry. PDLSCs inevitably acquire a senescent phenotype after prolonged in vitro expansion, and the key regulators of cells during replicative...

2022-11-15 | MTBLS4568 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
MetabolomicsEndo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation (Lipid Samples)
Not available
ORGANISM(S): Homo sapiens 
ST002142 | MetabolomicsWorkbench
MetabolomicsEndo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation (Media Samples)
Not available
ORGANISM(S): Homo sapiens 
ST002143 | MetabolomicsWorkbench
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079956 | MassIVE
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