Sort   by:  
 Page size 
ModelsMbodj2016 - Mesoderm specification during Drosophila development
Mbodj2016 - Mesoderm specification during Drosophila development This model is described in the article: Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes. Mbodj A, Gustafson EH, Ciglar L, Junion G, Gonzale...
2016-10-25 | MODEL1607310000 | BioModels
TranscriptomicsIn vitro cultured H7 human embryonic stem cells (WiCell) and H7-derived downstream early mesoderm progenitors
Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive developmental roadmaps are crucial to channel stem-cell differentiation toward desired fates. To this end, here, we map bifurcating lineage c...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-85066 | biostudies-arrayexpress
ProteomicsDiverse Fgfr1 signaling pathways and endocytic trafficking regulate early mesoderm development
The Fibroblast growth factor (FGF) pathway is a conserved signaling pathway required for embryonic development. Activated FGF receptor 1 (FGFR1) drives multiple intracellular signaling cascade pathways, including ERK/MAPK and PI3K/AKT, collectively termed canonical signaling. However, unlike Fgfr1 n...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD050632 | Pride
Fgf  mesoderm development  kidney development  cell signaling  cell adhesion  endocytic trafficking 
TranscriptomicsRNA-seq of wild-type and PGR (progesterone receptor) knockout pluripotent mouse EpiSCs (epiblast stem cells) and differentiated samples derived from these cell lines (primitive streak and mesoderm)
EpiSCs (epiblast stem cells) are murine pluripotent stem cells derived from the epiblast of a post-implantation embryo. These cells are primed to differentiate towards embryonic germ layers and are a useful model to study these early developmental events. PGR (progesterone receptor) is a nuclear rec...
ORGANISM(S): Mus musculus 
2022-11-30 | E-MTAB-12104 | biostudies-arrayexpress
TranscriptomicsPharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory netw...
ORGANISM(S): Mus musculus 
2012-11-26 | E-GEOD-42389 | biostudies-arrayexpress
TranscriptomicsIdentification of TWIST1 transcriptoinal targets in the cranial mesoderm [WNT1 vs. MESP1]
TWIST1, a basic helix-loop-helix transcription factor is essential for the development of cranial mesoderm and cranial neural crest-derived craniofacial structures. Our previous work showed that, in the absence of TWIST1, some cells within the cranial mesoderm adopt an abnormal epithelial configurat...
ORGANISM(S): Mus musculus 
2016-08-23 | E-GEOD-80335 | biostudies-arrayexpress
GenomicsParaxial mesoderm organoids model development of human somites
Paraxial mesoderm organoids model development of human somites
PRJNA799751 | ENA
TranscriptomicsRNAseq of mouse presomitic mesoderm segments along the anteroposterior embryo axis.
Somitogenesis is the segmentation of the developing embryonic body axis into somites and is guided by oscillating genes, which create waves of expression that travel across the presomitic mesoderm (PSM) from posterior to anterior. Upon arrival of a wave at the PSM's anterior end, a new somite is for...
ORGANISM(S): Mus musculus 
2017-12-01 | E-MTAB-6155 | biostudies-arrayexpress
TranscriptomicsTbx3 controls Dppa3 levels to regulate exit from pluripotency towards mesodermal lineage
Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs). However, we show that mESCs exist in an alternate stable pluripotent state in the absence of Tbx3. In-de...
ORGANISM(S): Mus musculus 
2015-07-21 | E-GEOD-60066 | biostudies-arrayexpress
TranscriptomicsThe Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Downregulating Components of the Death-Inducing Signaling Complex
A balance between cell survival and apoptosis is essential for animal development. Although proper development involves multiple interactions between germ layers, little is known about the intercellular and intertissue signaling pathways that promote cell survival in neighboring or distant germ laye...
ORGANISM(S): Xenopus laevis 
2011-02-21 | E-GEOD-26381 | biostudies-arrayexpress
Sort   by:  
 Page size