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MetabolomicsStability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation
Inflammatory bowel disease (IBD) is associated with altered microbiota composition and metabolism, but it is unclear whether these changes precede inflammation or are the result of it since current studies have mainly focused on changes after the onset of disease. We previously showed differences in...
2017-07-14 | MTBLS432 | MetaboLights
MetabolomicsInhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - NMR data

The global type 2 diabetes epidemic is a major health crisis and there is a critical need for innovative strategies to fight it. Although the microbiome plays important roles in the onset of insulin resistance (IR) and low-grade inflammation, the microbial compounds regulating these phenomena rem...

2025-10-20 | MTBLS12989 | MetaboLights
MetabolomicsInhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - LC-MS/MS data

The global type 2 diabetes epidemic is a major health crisis and there is a critical need for innovative strategies to fight it. Although the microbiome plays important roles in the onset of insulin resistance (IR) and low-grade inflammation, the microbial compounds regulating these phenomena rem...

2025-10-20 | MTBLS12975 | MetaboLights
MetabolomicsBlood metabolic panels for identifying significant fibrosis and inflammation in patients with MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) remains a prevalent condition with limited diagnostic and therapeutic options. This study aims to identify metabolic signatures of disease progression and develop non-invasive diagnostic models through three independent cohorts (inc...

2025-11-13 | MTBLS13268 | MetaboLights
MetabolomicsSurvival of the littlest: Navigating sepsis diagnosis beyond inflammation in preterm neonates
Background Sepsis diagnosis in preterm neonates is challenging due to symptom overlap with non-infectious inflammatory conditions, and slow, unreliable diagnostic practices. This study aims to identify metabolic biomarkers to elucidate sepsis pathophysiology, and enable timely, accurate diagnosis, w...
2025-07-07 | MTBLS10665 | MetaboLights
MetabolomicsImmunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation
Not available
ORGANISM(S): Mus musculus 
ST001255 | MetabolomicsWorkbench
MetabolomicsMoxibustion Inhibits Inflammation in Monosodium Urate Crystal-induced Gouty Arthritis Model Rats through Metabolomic Regulation

Background: Moxibustion is a form of therapy that to warm the acupoints located skin by using dried mugwort leaves. It is widely used to treat gouty arthritis (GA). However, the mechanism of moxibustion on improving GA has not been fully revealed. In this study, we explore the mechanism of moxibu...

2025-03-03 | MTBLS12225 | MetaboLights
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
MetabolomicsmTOR regulates metabolic adaptation of APCs in the lung microenvironment and controls the outcome of allergic inflammation
Not available
ORGANISM(S): Mus musculus 
ST000657 | MetabolomicsWorkbench
MetabolomicsPlasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy.

OBJECTIVE: Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs, and an established natural animal model for human epilepsy types with genetic and unknown etiology. However, the metabolic pathways underlying IE remain largely unknown. METHODS: Plasma samples of healthy...

2025-07-02 | MTBLS10915 | MetaboLights
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