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UnknownSECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.
Not available
S-EPMC5605228 | biostudies-literature
GenomicsMolecular basis for substrate recruitment to the PRMT5 methylosome
Molecular basis for substrate recruitment to the PRMT5 methylosome
PRJNA736940 | ENA
TranscriptomicsCharacterization and in vivo functional analysis of the Schizosaccharomyces pombe ICln gene
During the early steps of snRNP biogenesis, the Survival of Motor Neuron (SMN) complex acts together with the methylosome, an entity formed by the pICln protein, WD45 and the PRMT5 methyltransferase. To expand our understanding of pICln and SMN functional relationships in vivo, we performed a geneti...
ORGANISM(S): Schizosaccharomyces pombe 
2013-12-05 | E-GEOD-41403 | biostudies-arrayexpress
UnknownMethylosome protein 50 associates with the purinergic receptor P2X5 and is involved in osteoclast maturation.
Not available
S-EPMC6957751 | biostudies-literature
UnknownIn vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.
Not available
S-EPMC10578488 | biostudies-literature
UnknownMolecular basis for substrate recruitment to the PRMT5 methylosome.
Not available
S-EPMC9016627 | biostudies-literature
UnknownTIS7 induces transcriptional cascade of methylosome components required for muscle differentiation.
Not available
S-EPMC5080701 | biostudies-literature
TranscriptomicsRNA-seq analysis of 22Rv1 cells with PRMT5, MEP50, pICln knockdown
PRMT5 is a methyltransferase that catalyzes symmetric dimethylation of arginine residues in histones (H4R3, H3R8, H3R2, and H2AR3) to regulate transcription of target genes. While PRMT5 is generally considered an epigenetic repressor, recent evidence from our lab and others demonstrate that PRMT5 al...
ORGANISM(S): Homo sapiens 
2022-05-05 | GSE154951 | GEO
TranscriptomicsMolecular basis for substrate recruitment to the PRMT5 methylosome
PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP null cancers. PRMT5 utilizes adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily conserved peptide sequence shared among the three known substrate ad...
ORGANISM(S): Homo sapiens 
2021-06-12 | GSE177036 | GEO
TranscriptomicsAnalysis of differential gene expression in Drosophila dIME4 null mutants [single-end]
Methylation of mRNA at the N6 position of adenosin is known for a long time, but its function remains poorly understood. Here generated a null mutant in the catalytic subunit of the m6A mRNA methylosome, dIME4, in Drosophila to determine the impact of loss of m6A on gene expression using Illumina se...
ORGANISM(S): Drosophila melanogaster 
2016-09-22 | GSE78999 | GEO
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