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MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
TranscriptomicsWhole genome expression analysis of a skin biopsy from an individual with multi-organ epithelial inflammation associated with an inherited loss-of-function mutation in EGFR
Whole-genome expression microarray analysis was performed using RNA extracted from skin biopsies sampled from the affected child as well as 4 pooled, healthy controls. The hypothesis was that the downstream effects of the inherited EGFR loss-of-function mutation in the infant would be evident by enr...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-54162 | biostudies-arrayexpress
TranscriptomicsLoss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure.
RATIONALE: Heart failure is a deadly and devastating disease that places immense costs on an aging society. To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms underlying cardiomyocyte structure and function. OBJECTIVE: microRNAs are impor...
ORGANISM(S): Mus musculus 
2011-10-11 | E-GEOD-32881 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression from ARPE-19 cells: control and PDTC treated.
The cultured cell line ARPE-19 is frequently employed in studies of rpe function. Here we have identified the microRNAs expressed in RPE cells in the presence and absence of PDTC (pyrrolidine dithiocarbamate), an antioxidant. Analysis used microrNA extracted from untreated cells as a control for ce...
ORGANISM(S): Homo sapiens 
2010-07-24 | E-GEOD-23107 | biostudies-arrayexpress
TranscriptomicsAging and MicroRNA Expression in Human Skeletal Muscle
A common characteristic of aging is the loss of skeletal muscle (sarcopenia) which can lead to falls and fractures. MicroRNAs (miRNA) are novel post-transcriptional modulators of gene expression with a potential role as a regulator of skeletal muscle mass and function. The purpose of this study wa...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-23527 | biostudies-arrayexpress
ProteomicsSynthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation
MicroRNA (miRNA) sponges containing miRNA complementary binding sites constitute a potentially useful strategy for miRNA-inhibition therapeutics in cancer patients. Recently, naturally occurring circular RNAs (circRNAs) have been revealed to function as efficient microRNA sponges. We hypothesized th...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD008584 | Pride
Synthetic circular rna  microrna sponge  microrna loss of function  gastric carcinoma  gene therapy 
TranscriptomicsEvolution of human-specific microRNA miR-941 [cerebellum gene expression]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-35619 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941 [miRNA transfection]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Macaca mulatta 
2012-12-20 | E-GEOD-35620 | biostudies-arrayexpress
TranscriptomicsA variety of Dicer substrates in human and C. elegans (CEL RNA-seq)
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been directly mapped. Here, we apply biochemical methods to human cells and C. elegans and identify thousands of Dicer binding site...
ORGANISM(S): Caenorhabditis elegans 
2014-11-20 | E-GEOD-63435 | biostudies-arrayexpress
TranscriptomicsAAV vector-mediated in vivo miRNA antagonism for studying miRNA function and treating dyslipidemia
Understanding the function of individual miRNA species in mice would require the production of hundreds of loss-of-function strains. To accelerate analysis of miRNA biology in mammals, we combined recombinant adeno-associated virus (rAAV) vectors with miRNA ‘Tough Decoys’ (TuDs) to inhibit specific ...
ORGANISM(S): Mus musculus 
2011-12-10 | E-GEOD-25971 | biostudies-arrayexpress
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