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ProteomicsSynthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation
MicroRNA (miRNA) sponges containing miRNA complementary binding sites constitute a potentially useful strategy for miRNA-inhibition therapeutics in cancer patients. Recently, naturally occurring circular RNAs (circRNAs) have been revealed to function as efficient microRNA sponges. We hypothesized th...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD008584 | Pride
Synthetic circular rna  microrna sponge  microrna loss of function  gastric carcinoma  gene therapy 
TranscriptomicsEffects of miR-106a~363 blocking sponge on Sk-ES-1 Ewing Sarcoma Cell line Gene Expression Profile
The objective of this study was to determine the effects of miR-106a~363 blockade on the gene expression profile of Ewing Sarcoma cell lines (Sk-ES-1 cells) Microarray analysis was performed on 3 samples from Sk-ES-1 cells stably expressing the control CXCR4 miRNA sponge and 3 samples from Sk-ES-1 c...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-45205 | biostudies-arrayexpress
TranscriptomicsEffects of miRNA sponge/decoy-mediated reduction of miR-15 family activity on the transcriptome of B cell precursors
A common experimental setup to investigate the function of a microRNA is a â??gain-of-functionâ?? approach, in which the microRNA of interest is overexpressed to analyze its impact on a given process. However, a major drawback of this technique is that microRNAs, when expressed significantly above e...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-72767 | biostudies-arrayexpress
TranscriptomicsSequencing of Danio rerio brain from wildtype and Tg-microRNA-sponge animals
Comparison of gene expression profiles from Danio rerio brain of wiltype and Tg-microRNA-sponge animals. The RNA-seq data comprise 3 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
ORGANISM(S): Danio rerio 
2021-10-19 | GSE103134 | GEO
UnknownDelivery of microRNA-21-sponge and pre-microRNA-122 by MS2 virus-like particles to therapeutically target hepatocellular carcinoma cells.
Not available
S-EPMC8649937 | biostudies-literature
TranscriptomicsmiR-132 knockdown in rat PC12 cells
rat PC-12 cells were infected with a lentivirus expressing a sponge cassette to knockdown the expression of miR-132. Agilent whole rat genome arrays were probed to screen for changes in miR-132 knockdown cells versus control infected cells.
ORGANISM(S): Rattus norvegicus 
2011-07-15 | E-MTAB-458 | biostudies-arrayexpress
TranscriptomicsRNA-seq in breast cancer cell lines after manipulation of miR-23b expression
RNA sequencing technology has been carried out in order to evaluate mRNA expression changes after manipulation of miR-23b in both MCF-7 and MDA-MB-231 breast cancer cell lines Our study implicates miR-23b in cytoskeletal remodeling in breast cancer. To evaluate the entire set of genes modulated by m...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-37918 | biostudies-arrayexpress
UnknownCircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth.
Not available
S-EPMC6385474 | biostudies-literature
UnknownSponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina.
Not available
S-EPMC3173082 | biostudies-literature
TranscriptomicsmicroRNA profiles of nasopharyngeal carcinoma cell line and nasopharyngeal epithelial cell line
Exosomal and cellular miRNA expression levels were measured using a microRNA chip array or quantitative reverse transcription PCR (qRT-PCR). miR-24-3p was enriched in T-EXOs from the sera of NPC patients and NPC cells, which was correlated with worse disease-free survival (DFS). Exosomes (miR-24-3p-...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-76527 | biostudies-arrayexpress
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