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TranscriptomicsMicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins (HG-U133 2.0)
Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of disease biomarkers. Here we present evidence that human high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities. Highly-purified fracti...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-25311 | biostudies-arrayexpress
TranscriptomicsmiRNA signatures of intracellular and extracellular fractions from cancer cell lines
For the purpose of finding a novel tumor marker, we conducted microRNA profiling analysis in fractions of cells, exosomes, and culture medium from seven cancer cell lines. Ranking data of the intracellular and extracellular microRNAs obtained by microarray analysis, we found that let-7 microRNA fami...
ORGANISM(S): Homo sapiens 
2010-04-16 | E-GEOD-21350 | biostudies-arrayexpress
TranscriptomicsIntracellular and extracellular microRNAs expressed by HEK293T cells
MicroRNAs (miRNAs) are a class of small RNA molecules that regulate expression of specific mRNA targets. They can be released from cells, often encapsulated within extracellular vesicles (EVs), and therefore have the potential to mediate intercellular communication. It has been suggested that certai...
ORGANISM(S): Homo sapiens 
2012-06-25 | E-GEOD-38916 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling in hPASMC isolated from normal and PAH patients
To identify dysregulated miRNAs in PAH HPASMC, we compared the miRNA expression profiles between normal and PAH HPASMC using the RT2 miRNA PCR Array System. Total RNA was isolated using a miRNeasy Mini Kit (Qiagen, Valencia, CA) and treated with an RNase-Free DNase Set (Qiagen). After quantification...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-55427 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomic analysis of human and Drosophila extracellular vesicles reveals extensive conservation
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevai...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-76173 | biostudies-arrayexpress
ProteomicsProteomic profile of human CHME3 microglia in response to the miR-124-3p modulation in Swedish neuronal cells
We aim to evaluate how the levels of miR-124 in APPSwedish neuronal change the signature of interferon-gamma-stimulated human microglia, in a co-culture system. We want to fing possible pathways involved in cell-to-cell signaling and traficking, as well as inflammation-associated and miRNA targets i...
ORGANISM(S): Homo sapiens (Human) 
2022-06-02 | PXD030315 | Pride
Neuron-microglia crosstalk  mirna intercellular signaling  neuroimmune function  vesicular traficking 
TranscriptomicsMicroRNA expression changes associated with specific STAT3 activation
Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor in cancer. However, while the protein-coding target genes of STAT3 have been extensively studied, the microRNA target genes of STAT3 are less understood. MicroRNAs are short, non-coding RNAs that regulate m...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-44089 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of glial progenitor cells in growth and differentiation conditions
The molecular basis of astrocyte differentiation and maturation is poorly understood. As microRNAs have important roles in cell fate transitions, we set out to study their function during the glial progenitor cell (GPC) to astrocyte transition. Inducible deletion of all canonical microRNAs in GPCs i...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-64661 | biostudies-arrayexpress
TranscriptomicsmiRNA analysis of HBMVECs exposed or unexposed to U87 glioma cells
A key step in angiogenesis is the upregulation of growth factor receptors on endothelial cells. Here we demonstrate that a small regulatory microRNA, miR-296 has a major role in this process. Glioma cells and angiogenic growth factors elevate the level of miR-296 in primary human brain microvascular...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-13091 | biostudies-arrayexpress
GenomicsPlasma exosomal miRNA profiles in pediatric fulminant myocarditis patients and healthy controls
The pathophysiology of fulminant myocarditis (FM) is significantly influenced by the interactions between immunological and myocardial cells, involving exosome-mediated intercellular microRNA (miRNA) signaling. To further investigate the pathogenesis of FM and discover diagnostic biomarkers, we have...
ORGANISM(S): Homo sapiens 
2023-05-02 | GSE221090 | GEO
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