Sort   by:  
 Page size 
MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
MetabolomicsControlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-24 | MTBLS12437 | MetaboLights
ProteomicsProteomic Analysis of Retinal Mitochondria-associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-term Diabetes
The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical contact site between the ER and the mitochondria and plays a vital role in the regulation of calcium trafficking and bioenergetics. Previous studies suggest that disturbances in calcium trafficking and dysregulatio...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-15 | PXD033040 | Pride
Diabetic retinopathy  type 1 diabetes  mitochondria-associated er membrane  proteomic  retinal degeneration 
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
ProteomicsLiver mitochondria-associated ER membrane proteomics for studying the effects of ZiBuPiYin recipe on Zucker diabetic fatty rats after chronic psychological stress
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease with multiple etiologies, involving both genetic and environmental factors. With changes associated with modern life, increasing attention has been paid to chronic psychological stressors such as work stress. Chronic psychological stress...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-25 | PXD029226 | Pride
Type 2 diabetes mellitus Chronic psychological stress Zibupiyin recipe Proteomics Mitochondria-associated er membrane 
GenomicsGSAP regulates mitochondrial function through Mitochondria-associated ER membrane in the pathogenesis of Alzheimer’s disease
GSAP regulates mitochondrial function through Mitochondria-associated ER membrane in the pathogenesis of Alzheimer’s disease
PRJNA663585 | ENA
MetabolomicsNatural photosynthetic system for restoring homeostasis of animal organelle interaction network

Disruption of organelle interactions due to metabolic stress is a crucial factor in the pathological processes of many degenerative diseases. Current treatments usually focus on individual organelles while ignoring the role of organelle interactions in cell damage caused by cascade reactions. The...

2026-01-20 | MTBLS13730 | MetaboLights
UnknownGRP75-faciliated Mitochondria-associated ER Membrane (MAM) Integrity controls Cisplatin-resistance in Ovarian Cancer Patients.
Not available
S-EPMC9066115 | biostudies-literature
GenomicsDisruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) integrity identified in FUS‑mutant oligodendroglial progeny from human induced pluripotent stem cells
Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) integrity identified in FUS‑mutant oligodendroglial progeny from human induced pluripotent stem cells
PRJNA999223 | ENA
UnknownTFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts.
Not available
S-EPMC8479621 | biostudies-literature
Sort   by:  
 Page size