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The anticancer human mTOR inhibitor MLN0128/Sapanisertib with potent multistage in vitro antiplasmodium activity and in vivo antimalarial efficacy in a humanised mouse model is an inhibitor of multiple Plasmodium falciparum kinases.
Not available
ORGANISM(S):
Plasmodium falciparum
ST002011
|
MetabolomicsWorkbench
Cite
Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth.
Not available
S-EPMC4872734
|
biostudies-literature
Cite
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.
Not available
S-EPMC5696057
|
biostudies-literature
Cite
Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma.
Not available
S-EPMC6381283
|
biostudies-literature
Cite
Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia.
Not available
S-EPMC3593948
|
biostudies-literature
Cite
Preclinical trial of a new dual mTOR inhibitor, MLN0128, using renal cell carcinoma tumorgrafts.
Not available
S-EPMC4365782
|
biostudies-literature
Cite
Initial testing (stage 1) of the investigational mTOR kinase inhibitor MLN0128 by the pediatric preclinical testing program.
Not available
S-EPMC4248662
|
biostudies-literature
Cite
MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells.
Not available
S-EPMC5342403
|
biostudies-literature
Cite
A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer.
Not available
S-EPMC6050986
|
biostudies-literature
Cite
Use of dual mTOR inhibitor MLN0128 against everolimus-resistant breast cancer.
Not available
S-EPMC6026053
|
biostudies-literature
Cite
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