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TranscriptomicsMolecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
Introduction: Five different molecular subtypes of breast cancer have been identified through gene expression profiling. Each subtype has a characteristic expression pattern suggested to partly depend on cellular origin. We aimed to investigate whether the molecular subtypes also display distinct me...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22210 | biostudies-arrayexpress
TranscriptomicsDifferent molecular pathways along with pathogenesis of three subtypes of Leiomyosarcoma
Leiomyosarcoma (LMS) is a malignant neoplasm of smooth muscle and is an aggressive soft tissue tumor, have complex genetic abnormalities and could be defined as three molecular subtypes. Since that the molecular heterogeneity of LMS, the pathogenesis analysis per subtype will be highly necessary and...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-54511 | biostudies-arrayexpress
TranscriptomicsIntrinsic glioma subtypes in EORTC 26951 (part 6)
Background: Intrinsic glioma subtypes (IGS) are molecularly similar tumors that can be identified based on unsupervised gene-expression analysis. Here, we have evaluated the clinical relevance of these subtypes within EORTC26951, a randomized phase III clinical trial investigating adjuvant procarbaz...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43353 | biostudies-arrayexpress
TranscriptomicsMolecular subtypes of DLBCL have distinct chromosomal aberrations
We performed array comparative genomic hybridization (aCGH) and gene expression profiling in 203 samples of diffuse large B cell lymphoma (DLBCL). By gene expression, at least three molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) DLBCL, activated B cell-like (ABC) DLBCL, and ...
ORGANISM(S): Homo sapiens 
2008-09-04 | E-GEOD-11318 | biostudies-arrayexpress
ProteomicsMolecular Profiling Defines Three Subtypes of Synovial Sarcoma
Synovial Sarcomas (SS) are characterized by the presence of the SS18::SSX fusion gene, which protein product induce chromatin changes through remodeling of the BAF complex (BRG1/BRM-associated factor complex), which leads to widespread alterations in gene expression that drive tumor development and ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053789 | Pride
Synovial sarcoma  transcriptomics  multi-omic  molecular subtypes  proteomics 
TranscriptomicsStratification of Leiomyosarcoma molecular subtypes by 3' end RNA-sequencing: Toward precision medicine
Leiomyosarcoma (LMS) is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no targeted therapy currently exists for LMS. We demonstrate the existence of 3 molecular subtypes in a cohort of 99 cases and an independent cohort of 82 LMS. Tw...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-45510 | biostudies-arrayexpress
TranscriptomicsMicroarray-based molecular subtyping of breast cancer
The primary goal of this study is to identify molecular subtypes of breast cancer through gene expression profiles of 327 breast cancer samples and determine molecular and clinical characteristics of different breast cancer subtypes. We studied expression signatures of different cellular functions (...
ORGANISM(S): Homo sapiens 
2011-04-24 | E-GEOD-20685 | biostudies-arrayexpress
GenomicsMolecular subtypes in gastric cancer. [III]
Molecular subtypes in gastric cancer. [III]
PRJNA613226 | ENA
TranscriptomicsDNA methylation signatures define molecular subtypes of Diffuse Large B Cell Lymphoma
We performed DNA methylation (HELP array) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by gene expression, two molecular subtypes of DLBCL termed as "germinal center B cell-like" (GCB) and "activated B cell-like" (ABC) DLBCL were as...
ORGANISM(S): Homo sapiens 
2010-08-08 | E-GEOD-23501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancers to define clinically distinct molecular subtypes in estrogen receptor positive breast carcinomas using genomic grade
Purpose: A number of microarray studies have reported distinct molecular profiles of breast cancers (BC): basal-like, ErbB2-like and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognize...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-6532 | biostudies-arrayexpress
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