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MetabolomicsTranslational repression of viral RNA mediates arbovirus persistence in mosquitoes

Persistent infection of mosquito vectors is essential for the transmission of arboviruses, yet how these viruses produce sufficient progeny without compromising host cell fitness remains unclear. Arbovirus genomes exhibit suboptimal codon usage for both human and mosquito hosts, raising questions...

2026-02-12 | MTBLS12760 | MetaboLights
MetabolomicsA Plastoglobuli-Localized Enzyme Links Phenylalanine Biosynthesis to Translational Homeostasis in Maize
Aromatic amino acids are essential precursors for numerous plant metabolites, with phenylalanine (Phe) forming the basis of the phenylpropanoid pathway. Here, we reveal a critical mechanism for Phe biosynthesis in maize, demonstrating that all seven arogenate dehydratases (ADTs) are specifically loc...
2026-06-25 | MTBLS14853 | MetaboLights
MetabolomicsA Plastoglobuli-Localized Enzyme Links Phenylalanine Biosynthesis to Translational Homeostasis in Maize
Aromatic amino acids are essential precursors for numerous plant metabolites, with phenylalanine (Phe) forming the basis of the phenylpropanoid pathway. Here, we reveal a critical mechanism for Phe biosynthesis in maize, demonstrating that all seven arogenate dehydratases (ADTs) are specifically loc...
2026-06-25 | MTBLS14852 | MetaboLights
MetabolomicsThe splicing paralogues SNRPB and SNRPN control differential metabolic states

Gene duplication is a major driver of biological complexity, yet the persistence of highly similar paralogous factors suggests the existence of context-dependent functions that remain incompletely understood. Certain conserved components of the mammalian RNA processing machinery exhibit striking ...

2026-02-09 | MTBLS13877 | MetaboLights
TranscriptomicsTranslational control in early adipogenesis
In obesity, adipose tissue expands by increasing the volume of existing adipocytes (hypertrophy), increasing the number of small adipocytes (hyperplasia) or both. Much is known about transcriptional control during adipogenesis, including early events. However, translational control plays a pivotal r...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-29744 | biostudies-arrayexpress
TranscriptomicsCoding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation
It is well established that small noncoding RNAs (sRNAs) of bacteria recognize the 5â?? regions of target mRNAs, generally at the ribosome binding site. Until now, the translated coding sequence (CDS) of mRNA appeared to be refractory to sRNA interactions. We have discovered that Salmonella MicC RNA...
ORGANISM(S): Salmonella enterica 
2010-05-16 | E-GEOD-16540 | biostudies-arrayexpress
TranscriptomicsPoly(A)-tail profiling reveals an embryonic switch in translational control
Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function. Here we describe poly(A)-tail length profiling by sequencing (PAL-seq) and apply it to measu...
ORGANISM(S): Arabidopsis thaliana 
2014-01-29 | E-GEOD-52809 | biostudies-arrayexpress
TranscriptomicsTranslational control: a new dimension in the regulation of Arabidopsis photomorphogenesis
The environmental “light” plays a vital role in regulating the plant growth and development. Transcriptomic profilings were widely used to examine how light regulates the changes of mRNA populations at a genome-wide scale. However, it remains unclear if translational regulation represents a new dime...
ORGANISM(S): Arabidopsis thaliana 
2012-07-10 | E-GEOD-29657 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Ki-ras transformed embryo prostate epithelial cells (267B1) to identify mRNAs under differential translational control
The purpose of the experiment is to identify mRNAs under differential translational control in Ki-ras transformed 267B1 cells as compared to the parental cell line. Total and polysome-associated mRNAs were isolated from exponentially growing cells and used to prepare biotin-labeled cRNA probes for ...
ORGANISM(S): Homo sapiens 
2007-06-26 | E-MEXP-461 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid effect on mRNA translation in childhood acute lymphoblastic leukemia
Glucocorticoids (GCs) are a central component in treating childhood acute lymphoblastic leukemia (chALL). They mainly act via regulating gene transcription. However, control of mRNA translation by GC has never been assessed systematically. In our research, T- and precursor B-ALL cells were cultured ...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-48680 | biostudies-arrayexpress
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