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ProteomicsMapping of mycobacterial lipolytic enzymes involved in triacylglycerol accumulation as intrabacterial lipid inclusions using multi-target inhibitor-like affinity-based probes
Mycobacteria are known for their unique and complex cell wall architecture, characterized by distinct lipid-rich outer layers, making lipid metabolism a central point of their physiological processes. One crucial aspect of all mycobacteria is their ability to metabolize host lipids and to accumulate...
ORGANISM(S): Mycobacterium abscessus 
2025-05-12 | PXD048770 | Pride
Mycobacterium Lc_msms Activity-based protein profiling  multitarget inhibitor-like affinity-based probes  lipid metabolism  cyclipostins & cyclophostin  oxadiazolone 
ProteomicsSynthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus and other Pathogenic Mycobacteria
Targeting the enzymes involved in mycobacterial lipid metabolism; which are mainly serine and cysteine enzymes (i.e., (Ser/Cys)-based enzymes; has emerged as a promising strategy to combat not only M. tuberculosis, but also other chronic non-tuberculous mycobacterial infections like those caused by ...
ORGANISM(S): Mycobacterium tuberculosis Mycobacteroides abscessus subsp. abscessus Bacteria 
2025-04-23 | PXD057836 | Pride
Activity-based protein profiling  multitarget inhibitor-like affinity-based probes  drug susceptibility  intracellular activity  proteomic analysis  mycobacteria  lc-msms 
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