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TranscriptomicsTranscription profiling of mouse models with liver-specific deletion or global hypomorphic expression of the NADPH-cytochrome P450 reductase gene to study molecular mechanisms for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
NADPH-cytochrome P450 reductase (CPR) is important for the functions of many enzymes, such as microsomal cytochrome P450 (P450) monooxygenases and heme oxygenases. Two mouse models with deficient CPR expression in adults were recently generated in this laboratory: liver-Cpr-null (with liver-specific...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2362 | biostudies-arrayexpress
TranscriptomicsAltered gene expression in the small intestine of IE-Cpr-null mice
The NADPH-cytochrome P450 reductase (CPR) is essential for the functioning of microsomal cytochrome P450 (P450) monoxygenases. The biological functions of the CPR-dependent enzymes in the intestine are not known, despite the vast knowledge available on the biochemical properties of the various oxyge...
ORGANISM(S): Mus musculus 
2012-04-10 | E-GEOD-35293 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse colon response to quercetin in WT and POR-null animals
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4256 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver response to quercetin in WT and POR-null mice
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4259 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ileum response to quercetin in WT and POR-null mice
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4257 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse POR-null and wild type jejunum response to quercetin
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4258 | biostudies-arrayexpress
ProteomicsAlternative splicing of Arabidopsis G6PD5 can recruits the NADPH-producing OPPP reactions to the endoplasmic reticulum
Glucose-6-phosphate dehydrogenase is the rate-limiting enzyme of the oxidative pentose-phosphate pathway (OPPP). The OPPP mainly provides NADPH and sugar-phosphate building blocks for anabolic pathways and is present in all eukaryotes. In plant cells, the irreversible part of the OPPP is found in se...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
PXD035221 | JPOST Repository
UnknownAllosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain.
Not available
S-EPMC10481364 | biostudies-literature
UnknownGenomic and bioinformatic analysis of NADPH-cytochrome P450 reductase in Anopheles stephensi (Diptera: Culicidae).
Not available
S-EPMC5443604 | biostudies-literature
UnknownNADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family.
Not available
S-EPMC3606592 | biostudies-literature
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