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ProteomicsLC-MS characterization of anti-PD-L1 and CXCR4 bispecific nanobodies
Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer. Here, we designed a nanobody molecule with bi-targeting on PD-L1 and CXCR4, as both targets are overexpressed i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037102 | Pride
Nanobody Lc-ms Bispecific Protein Complete mw 
GenomicsBiparatopic anti-spike nanobody
Resistance to anti-spike nanobody.
PRJEB49553 | ENA
UnknownNanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression.
Not available
S-EPMC10688028 | biostudies-literature
ProteomicsA Nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation
Fascin-1 mediated actin-bundling activity is central to the generation of plasma membrane protrusions required for cell migration. Dysregulation of cellular protrusions is observed in metastatic cancers, where they are required for increased invasiveness, and this is often correlated with overexpres...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD038713 | Pride
Fascin-1 Hydrogen deuterium exchange Nanobody Hdx 
ProteomicsTargeted deglycosylation with a nanobody-directed split OGA in living cells
O-GlcNAc is an essential and dynamic post-translational modification present on thousands of nucleocytoplasmic proteins. Interrogating the role of O-GlcNAc on a target protein in cells is critical yet challenging without disturbing O-GlcNAc globally or after extensive glycosite mapping. Herein, we d...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD018914 | Pride
O-glcnac  nanobody  oga  c-jun 
UnknownNanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy.
Not available
S-EPMC7904846 | biostudies-literature
UnknownNanobody Technology: A Versatile Toolkit for Microscopic Imaging, Protein-Protein Interaction Analysis, and Protein Function Exploration.
Not available
S-EPMC5495861 | biostudies-literature
ProteomicsNoncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing globally in recent years. The development of immunotherapies for colon cancer is critical for providing new treatment strategies to combat drug resistanc...
ORGANISM(S): Escherichia coli 
2026-01-12 | PXD069482 | Pride
Bispecific antibody Maldi-tof Noncanonical amino acid 
GenomicsiMbody - a nanobody for i-Motif research
iMbody - a nanobody for i-Motif research
PRJNA877220 | ENA
UnknownA novel anti-CTLA-4 nanobody-IL12 fusion protein in combination with a dendritic cell/tumour fusion cell vaccine enhances the antitumour activity of CD8<sup>+</sup> T cells in solid tumours.
Not available
S-EPMC11490160 | biostudies-literature
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