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ProteomicsThe nitrobenzoxadiazole derivative NBDHEX behaves as Plasmodium falciparum gametocyte selective inhibitor with malaria parasite transmission blocking activity
This work describes the activity of 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX) and of its newly identified carboxylic acid metabolite on human malaria parasite Plasmodium falciparum. NBDHEX has been previously identified as a potent cytotoxic agent against murine and human can...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2022-03-03 | PXD030336 | Pride
Malaria  plasmodium falciparum transmission  nbdhex  mass spectrometry 
UnknownNBDHEX re-sensitizes adriamycin-resistant breast cancer by inhibiting glutathione S-transferase pi.
Not available
S-EPMC10028113 | biostudies-literature
UnknownProteomic and functional analyses reveal pleiotropic action of the anti-tumoral compound NBDHEX in Giardia duodenalis.
Not available
S-EPMC5377010 | biostudies-literature
UnknownAugmentation of the Benzyl Isothiocyanate-Induced Antiproliferation by NBDHEX in the HCT-116 Human Colorectal Cancer Cell Line.
Not available
S-EPMC12428750 | biostudies-literature
UnknownThe Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity.
Not available
S-EPMC8875241 | biostudies-literature
UnknownTargeting hypoxia-mediated chemo-immuno resistance by a hybrid NBDHEX-Pt(IV) prodrug via declining nuclear STING1-promoted AhR-CIN in human lung squamous cell carcinoma.
Not available
S-EPMC11985067 | biostudies-literature
UnknownA new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability.
Not available
S-EPMC6009906 | biostudies-literature
TranscriptomicsMicrophysiological System Modeling of Ochratoxin A-Associated Nephrotoxicity
Ochratoxin A (OTA) is one of the most abundant mycotoxin contaminants in food stuffs and possesses carcinogenic, nephrotoxic, teratogenic and immunotoxic properties. Especially, severe nephrotoxicity is of great concern, as characterized by degeneration of epithelial cells of the proximal tubules an...
ORGANISM(S): Homo sapiens 
2020-10-22 | GSE151776 | GEO
UnknownThe fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex.
Not available
S-EPMC4040697 | biostudies-literature
UnknownDownregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1.
Not available
S-EPMC10372835 | biostudies-literature
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