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TranscriptomicsIntrinsic age-dependent changes and cell-cell contacts regulate nephron progenitor lifespan
Purpose: To use single-cell RNA-Seq analysis of nephron progenitors in order to determine transcrptional differences as nephron progenitors age. Methods: Using a combination of FACS sorting and a Fluidigm Single-cell auto-prep system, we generated high-throughput RNA-SEQ data of nephron progenitors ...
ORGANISM(S): Mus musculus 
2015-12-23 | E-GEOD-66202 | biostudies-arrayexpress
Transcriptomicsp53 Enables Self Renewal of Nephron Progenitor Cells
p53 limits the self-renewing ability of a variety of stem cells. Here, contrary to its classical role in restraining cell proliferation, we demonstrate a divergent function of p53 in maintenance of self-renewal of the nephron progenitor population in the embryonic mouse kidney. p53-null nephron prog...
ORGANISM(S): Mus musculus 
2015-02-16 | E-GEOD-56253 | biostudies-arrayexpress
GenomicsLGR6 marks nephron progenitor cells
LGR6 marks nephron progenitor cells
PRJNA691957 | ENA
GenomicsGeneration of induced nephron progenitor-like cells from human urine-derived cells
Generation of induced nephron progenitor-like cells from human urine-derived cells
PRJNA554095 | ENA
GenomicsGene expression profile of human iPSC-derived nephron progenitor cells
Gene expression profile of human iPSC-derived nephron progenitor cells
PRJNA486586 | ENA
GenomicsMapping open chromatin in mouse nephron progenitor cells
Mapping open chromatin in mouse nephron progenitor cells
PRJNA427367 | ENA
GenomicsTranscriptional profiling of human and mouse nephron progenitor cells
Transcriptional profiling of human and mouse nephron progenitor cells
PRJNA298246 | ENA
TranscriptomicsGene expression comparison of E14.5 Foxd1 null and wild type kidneys
Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 is required during kidney development and its inactivation results in failure of nephron progenitor cell differentiation. Foxd1 is expressed in interstitial cells adjacent to ne...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52354 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in nephron progenitors lacking miR-17~92
Purpose: The goal of this study is to compare the differential expression of transcripts in control kidneys compared to kidneys lacking the miR-17~92 cluster in nephron progenitors and their derivatives by RNA-seq to identify potential miRNA targets in the mutant kidneys. mRNA profiles of control an...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-52514 | biostudies-arrayexpress
GenomicsGenome-wide chromatin accessibility (ATAC-Seq) of primary murine nephron progenitor cells.
Genome-wide chromatin accessibility (ATAC-Seq) of primary murine nephron progenitor cells.
PRJNA930634 | ENA
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