Background: Triple-negative breast cancer (TNBC) urgently needs effective therapies due to limited targeted options and unfavorable outcomes. We investigated Trichosanthes kirilowii Maxim formula granules (TKM) using integrated network pharmacology, metabolomics, and molecular pharmacology to cla...

Cardiovascular adverse effects caused by high-intensity exercise (HIE) have become a public health problem of widespread concern. As a phytochemical with potential therapeutic effects, the therapeutic effect and metabolic regulation mechanism of myricetin have rarely been studied. In this study, ...

Objective: The leaves of Malus hupehensis (MH) are a medicinal and edible traditional Chinese medicine (TCM) with good liver protection, although its underlying mechanism remains unclear. In this study, a network pharmacology-integrated multi-omics method was used to explore the hepatoprotective ...

Background: Clinacanthus nutans (C. nutans), a Southeast Asian medicinal herb, has ethnopharmacological potential against nasopharyngeal carcinoma (NPC). This study aimed to elucidate the bioactive compounds, potential molecular targets, and regulatory pathways responsible for the anticancer acti...

The mechanisms by which probiotics ameliorate neurodegenerative diseases have garnered significant scientific interest, yet elucidating their underlying pathways remains challenging. In this study, we establish an integrated multi-omics and network pharmacology strategy to unravel the prote...

Background: Osteoarthritis (OA) is a debilitating joint disorder with no effective disease-modifying drugs. Liubao tea, a traditional Chinese dark tea, possesses various bioactivities, including anti-inflammatory and gut microbiota-regulating effects. However, its potential therapeutic role and m...