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MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
TranscriptomicsGene expression profiling of neuroendocrine primary tumors: effect of Octreotide treatment
The management of neuroendocrine tumors (NETs) is very variable, depending on many specific aspects, such as the type of tumor, spread and patient general health. Several advances have been made with the newly developed somatostatin analogues to cure this type of malignancies. Somatostain analogues ...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-24358 | biostudies-arrayexpress
ProteomicsRisk SNP rs11067228-mediated high-order chromatin interactions drive prostate cancer neuroendocrine differentiation through splicing factor SRRM4
Neuroendocrine prostate cancer is an aggressive disease characterized by early metastasis, drug resistance and poor prognosis. Genome-wide association studies (GWAS) previously identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer. SNP rs11067228 as a significant...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD055628 | Pride
Snp rs11067228  enhancer  long-range chromatin interaction  neuroendocrine differentiation  prostate cancer 
ProteomicsProteogenomic characterization of pancreatic neuroendocrine tumor
To characterize pancreatic neuroendocrine tumor at protein level, we performed mass spectromery-based proteome analysis using clinical FFPE tissue samples.
ORGANISM(S): Homo sapiens (Human) 
2024-07-10 | PXD034571 | Pride
Human Tissue Pancreatic neuroendocrine tumor 
TranscriptomicsArray CGH-based Characterization of Genetic Alterations in Pulmonary Neuroendocrine Tumors
The goal of this study was to characterize and classify pulmonary neuroendocrine tumors based on Array Comparative Genomic Hybridization (aCGH). Using aCGH, we performed karyotype analysis of 33 small cell lung cancer (SCLC) tumors, 13 SCLC cell lines, 19 bronchial carcinoids, and 9 gastrointestinal...
ORGANISM(S): Homo sapiens 
2010-04-22 | E-GEOD-21468 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human classical midgut carcinoid primary tumors and liver metastasis
We identify genes presenting a specific expression profile in midgut carcinoid cells, primary carcinoids tumors and liver metastasis were gene profiled. Gene expression profiling of classical midgut carcinoid primary tumors and liver metastasis reveal potential novel therapeutic targets and molecula...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-9576 | biostudies-arrayexpress
GenomicsASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
ChIP-Seq analysis performed on 5 ASCL1(+) cell lines and 2 ASCL1 (-) cell lines in order to understand the transcriptome of ASCL1 as it pertains to high-grade neuroendocrine lung cancers 5 ASCL1(+) lung cancer cell lines and 2 ASCL1(-) lung cancer cell lines were compared using ChIP-Seq analysis
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-61197 | biostudies-arrayexpress
UnknownEnhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications.
Not available
S-EPMC11474083 | biostudies-literature
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