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MetabolomicsPantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii
Coenzyme A (CoA) is an essential molecule acting in metabolism, post-translational modification, and regulation of gene expression. While all organisms synthesize CoA, many, including humans, are unable to produce its precursor, pantothenate. Intriguingly, like most plants, fungi and bacteria, paras...
2022-03-21 | MTBLS2501 | MetaboLights
MetabolomicsGlycerophospholipid remodeling is critical for orthoflavivirus infection

Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile and tick-borne encephalitis viruses, as well as dengue and yellow fever virus. Early in infection specific lipids accumulated, e.g., neutral...

2025-02-24 | MTBLS11030 | MetaboLights
MetabolomicsToxoplasma gondii infection induces metabolic alterations in the mouse cerebellum
Toxoplasma gondii is a protozoan parasite with a remarkable neurotropic affinity. We recently showed that T. gondii infection can alter the global metabolism of the cerebral cortex of the mice. However, the impact of this infection on the metabolism of the cerebellum remained unclear. In this study,...
2020-04-27 | MTBLS1537 | MetaboLights
GenomicsMAVS signaling shapes microglia responses to neurotropic virus infection
MAVS signaling shapes microglia responses to neurotropic virus infection
PRJNA1148457 | ENA
GenomicsThe CSF1R-Microglia Axis Has Protective Host-Specific Roles During Neurotropic Picornavirus Infection
The CSF1R-Microglia Axis Has Protective Host-Specific Roles During Neurotropic Picornavirus Infection
PRJNA673884 | ENA
TranscriptomicsSTAT1 independent control of a neurotropic measles virus challenge in primary neurons and infected mice
The objective of this study was to compare the ability of mice that lack STAT1 to resolve a neurotropic viral challenge, and to assess the ability of neurons obtained from these mice to be effectively cleared of virus by interferon gamma For the array, primary neurons were isolated from embryonic mi...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33057 | biostudies-arrayexpress
TranscriptomicsThe CSF1R-Microglia Axis Has Protective Host-Specific Roles During Neurotropic Picornavirus Infection
Goal: Determine the role of microglia in the antiviral response during neurotropic picornavirus infection of C57BL/6J and SJL/J mice and whether absence of microglia would affect CD4 and CD8 T cell functions. Methods: Brains from C57BL/6J and SJL/J mice treated with PLX5622 (to deplete microlgia) or...
ORGANISM(S): Mus musculus 
2021-05-10 | GSE160660 | GEO
UnknownMAVS signaling shapes microglia responses to neurotropic virus infection.
Not available
S-EPMC11490141 | biostudies-literature
GenomicsVEGFR3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
VEGFR3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
PRJNA952207 | ENA
UnknownSARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection.
Not available
S-EPMC9043327 | biostudies-literature
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