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ProteomicsCovalent histone modification by an electrophilic derivative of the anti-HIV drug nevirapine
Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor widely used in combined antiretroviral therapy and to prevent mother-to-child transmission of the human immunodefi-ciency virus type 1, is associated with several adverse side effects. Using 12-mesyloxy-nevirapine, a model electroph...
ORGANISM(S): Homo sapiens (Human) 
2021-03-08 | PXD023751 | Pride
Covalent histone modification  mass spectrometry  drug-induced adverse reactions  covalent protein adducts  nevirapine 
GenomicsThe role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury
The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury
PRJNA1073404 | ENA
UnknownClinical perspectives on human genetic screening to prevent nevirapine toxicity.
Not available
S-EPMC3579661 | biostudies-literature
TranscriptomicsThe role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury
Nevirapine, an antiretroviral used in the treatment of HIV, is associated with idiosyncratic drug-induced liver injury (IDILI), a potentially life-threatening adverse drug reaction. Its usage has decreased due to this concern, but it is still widely used in lower-resource settings. In general, the m...
ORGANISM(S): Mus musculus 
2024-04-15 | GSE255038 | GEO
TranscriptomicsTranscriptomic profiling in Malawian patients with acute hypersensitivity reactions to Nevirapine
Nevirapine is a non-nucleoside reverse transcriptase inhibitor, a class of antiretroviral drug, used for the treatment of HIV-1 infection. Despite its wide use, nevirapine treatment has been associated with a significant incidence of different kind of hypersensitivity reactions (HSRs). We used micro...
ORGANISM(S): Homo sapiens 
2015-11-30 | GSE42436 | GEO
TranscriptomicsTime course expression data from Brown Norway rat livers treated with nevirapine or galactosamine or both
Nevirapine alone produces only mild hepatic hypertrophy in the rat. Single ip dose galactosamine produces transient hepatocellular apoptotic and oncotic cell death mimicking viral hepatitis with portal inflammatory infiltrate and biliary hypertrophy and hyperplasia. Damage is typically resolved with...
ORGANISM(S): Rattus norvegicus 
2015-08-15 | GSE72076 | GEO
GenomicsHomo sapiens
Transcriptomic profiling in Malawian patients with acute hypersensitivity reactions to Nevirapine
PRJNA181968 | ENA
UnknownSlower clearance of nevirapine resistant virus in infants failing extended nevirapine prophylaxis for prevention of mother-to-child HIV transmission.
Not available
S-EPMC3149453 | biostudies-literature
UnknownAntiretroviral therapies in women after single-dose nevirapine exposure.
Not available
S-EPMC2994321 | biostudies-literature
UnknownAntiretroviral treatment for children with peripartum nevirapine exposure.
Not available
S-EPMC3021781 | biostudies-literature
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