Sort   by:  
 Page size 
ProteomicsInactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Since loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked if loss of Pak2, a highly expressed group I PAK member, affects the development of malignant mesothe...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD030571 | Pride
Conditional knockout mice  malignant mesothelioma  nf2 and cdkn2a tumor suppressor genes  pak  hedgehog and wnt signaling  cancer stem cells 
UnknownComprehensive Genomic Profiling of NF2-Mutated Kidney Tumors Reveals Potential Targets for Therapy.
Not available
S-EPMC10322144 | biostudies-literature
UnknownTumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53-miR-34a-c-Met axis.
Not available
S-EPMC3945416 | biostudies-literature
UnknownIntegrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2.
Not available
S-EPMC12924687 | biostudies-literature
TranscriptomicsLoss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [single_cell_RNAseq]
Pancreatic ductal adenocarcinoma (PDAC) occurs as a complex, multifaceted event driven by the interplay of tumor permissive genetic mutations, nature of cellular origin and microenvironmental stress. In this study, we present a novel model to screen previously underappreciated tumor suppressor genes...
ORGANISM(S): Homo sapiens 
2025-10-07 | GSE292513 | GEO
TranscriptomicsLoss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [bulk_RNAseq]
Pancreatic ductal adenocarcinoma (PDAC) occurs as a complex, multifaceted event driven by the interplay of tumor permissive genetic mutations, nature of cellular origin and microenvironmental stress. In this study, we present a novel model to screen previously underappreciated tumor suppressor genes...
ORGANISM(S): Homo sapiens 
2025-10-07 | GSE292512 | GEO
OtherLoss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [CRISPR_screen]
Pancreatic ductal adenocarcinoma (PDAC) occurs as a complex, multifaceted event driven by the interplay of tumor permissive genetic mutations, nature of cellular origin and microenvironmental stress. In this study, we present a novel model to screen previously underappreciated tumor suppressor genes...
ORGANISM(S): Homo sapiens 
2025-10-07 | GSE292511 | GEO
GenomicsLoss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [bulk_RNAseq]
Loss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [bulk_RNAseq]
PRJNA1238892 | ENA
GenomicsLoss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [single_cell_RNAseq]
Loss of NF2 drives malignant transformation of human pancreatic acinar cells and enhances cell fitness under nutrient deprivation and therapeutical stress [single_cell_RNAseq]
PRJNA1238891 | ENA
UnknownInactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling.
Not available
S-EPMC9081258 | biostudies-literature
Sort   by:  
 Page size