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MetabolomicsChronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.
Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric o...
2025-07-14 | MTBLS9526 | MetaboLights
MetabolomicsMulti-omics analysis of xylem sap uncovers dynamic modulation of poplar defenses by ammonium and nitrate
Xylem sap is the major transport route for nutrients from roots to shoots. In the present study, we investigated how variations in nitrogen (N) nutrition affected the metabolome and proteome of xylem sap and the growth of the xylem endophyte Brennaria salicis, and we also report transcriptional re-w...
2022-07-04 | MTBLS2305 | MetaboLights
MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
MetabolomicsNitrate Reductase NarGHJI Modulates Vancomycin Susceptibility by Coordinating Cell Wall Remodeling and Agmatine Metabolism in Staphylococcus aureus
Staphylococcus aureus is a ubiquitous pathogen responsible for a wide range of severe infections. Our previous work established that the nitrate reductase NarGHJI modulates bacterial pathogenicity through regulation of the agr system, yet its role in antibiotic resistance remains poorly understood. ...
2026-07-07 | MTBLS14968 | MetaboLights
TranscriptomicsH. seropedicae grown on nitrate (OD 0.8)
H. seropedicae SmR1 was grown on nitrate 10 mM as the only nitrogen source and harvested at an OD600 of 0.8.
ORGANISM(S): Herbaspirillum seropedicae SmR1 
2016-07-01 | E-MTAB-2842 | biostudies-arrayexpress
TranscriptomicsExpressionprofiling of a glnR-mutant of Mycobacterium tuberculosis during culture on nitrate
Identification of glnR-dependent regulation of nitrate assimilation Keywords: genetic modification Mycobacterium tuberculosis H37Rv wild type and glnR mutant strain were incubated in minimal medium supplemented with 5 mM NO3 for 18 and 48 hours. RNA was extracted at indicated time points and microa...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2010-06-20 | E-GEOD-13246 | biostudies-arrayexpress
TranscriptomicsNitrate Stress in Desulfovibrio vulgaris Hildenborough
Using data from microarray experiments, we investigated the effects of excess sodium nitrate on Desulfovibrio vulgaris. Keywords: stress response, time course Comparison of cells treated with 105 mM sodium nitrate to untreated cells at times of 0, 30, 60, 120, and 240 min.
ORGANISM(S): Desulfovibrio vulgaris str. Hildenborough 
2010-06-22 | E-GEOD-20079 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabdiopsis wild type and G'4-3 seeds grown with different nitrate concentrations to investigate effects on seed dormancy
Freshly harvested Arabidopsis seeds (ecotype Col0 obtained under 10 mM nitrate nutrition, referred to as C10 seeds) are dormant and do not germinate when sown on an agarose-based medium. However, when C10 seeds are sown on 10mM nitrate or when Col0 mother plants are grown on 50 mM nitrate (referred...
ORGANISM(S): Arabidopsis thaliana 
2007-01-31 | E-MEXP-447 | biostudies-arrayexpress
TranscriptomicsTranscriptional characterization of maize roots in response to urea and nitrate
Although urea is the most used nitrogen fertilizer worldwide, little is known on the capacity of crop plants to use urea per se as a nitrogen source for development and growth. To date, the molecular and physiological bases of its transport have been investigated only in a limited number of species....
ORGANISM(S): Zea mays 
2015-03-02 | E-GEOD-53102 | biostudies-arrayexpress
TranscriptomicsMeasuring transcriptional differences between Caulobacter crescentus cultured in nitrate versus ammonium as the sole nitrogen source
This study is measuring the steady-state levels of mRNA in wild-type Caulobacter crescentus grown in M2 defined medium containing either ammonium or nitrate as the sole nitrogen source. Four independent cultures of Caulobacter crecentus were grown in each of two medium conditions: M2(nitrate)glucose...
ORGANISM(S): Caulobacter vibrioides 
2010-06-20 | E-GEOD-21203 | biostudies-arrayexpress
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