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MetabolomicsLKB1 inactivation elicits a NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer
The protein arginine methyl transferase 5 (PRMT5) emerges as a therapeutic target in S-methyl-5'-thioadenosine phosphorylase (MTAP)-deleted cancers, where MTA accumulation partially inhibits its activity. However, It remains unclear whether other genetic alterations can dictate PRMT5 activity in can...
2026-04-30 | MTBLS14411 | MetaboLights
GenomicsH3K9me3, H3K27me3, H3K27ac and H3K4me3 ChIP-sequencing in SUM159PT NNMT-WT, NNMT-KOd and NNMT KOs breast cancer cells.
H3K9me3, H3K27me3, H3K27ac and H3K4me3 ChIP-sequencing in SUM159PT NNMT-WT, NNMT-KOd and NNMT KOs breast cancer cells.
PRJNA472964 | ENA
ProteomicsNAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment
Drugs targeting mutant oncogenes are effective, even though resistance rapidly develops. This complex picture includes acquired intrinsic tumor and tumor microenvironmental -mediated mechanisms. Here we showed that melanoma cells resistant to BRAF inhibitors (BRAFi) overexpressed the rate limiting e...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD063060 | Pride
Nampt  nnmt  metastatic melanoma  resistance  extracellular vesicles  secretome  signaling  tumor microenvironment 
GenomicsNNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (Nnmt overexpressing TEC cells) [Series_3]
NNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (Nnmt overexpressing TEC cells) [Series_3]
PRJNA1179389 | ENA
ProteomicsProteomics reveals NNMT as a master metabolic regulator of cancer associated fibroblasts
High-grade serous carcinoma has a poor prognosis, owing primarily to its early dissemination throughout the abdominal cavity. Genomic and proteomic approaches have provided snapshots of the proteogenomics of ovarian cancer, but a systematic examination of both the tumour and stromal compartments is ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-18 | PXD006396 | Pride
Ovarian cancer proteomics laser microdissection 
GenomicsRNA sequencing of NNMT overexpression in 3T3 fibroblasts
RNA sequencing of NNMT overexpression in 3T3 fibroblasts
PRJNA510587 | ENA
GenomicsMicroarray analysis of NNMT overexpression and knockdown in stromal cells
Microarray analysis of NNMT overexpression and knockdown in stromal cells
PRJNA447980 | ENA
GenomicsNNMT inhibition in cancer-associated fibroblasts restores antitumor immunity
NNMT inhibition in cancer-associated fibroblasts restores antitumor immunity
PRJNA1240623 | ENA
GenomicsH3K27 ChIP-sequencing of NNMT overexpression in normal fibroblasts
H3K27 ChIP-sequencing of NNMT overexpression in normal fibroblasts
PRJNA510590 | ENA
GenomicsNNMT inhibition in cancer-associated fibroblasts restores antitumor immunity.
NNMT inhibition in cancer-associated fibroblasts restores antitumor immunity.
PRJNA1252662 | ENA
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