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ProteomicsA lysine residue at the C-terminus of MHC class I ligands correlates with low C-terminal proteasomal cleavage probability
The majority of peptides presented by MHC class I results from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases can, either alone or together with the proteasome...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044235 | Pride
Immunopeptidomics  proteasome-independent  non-canonical mhc class i ligands  hla-a*03:01  hla-a*11:01  hla-a*30:01  proteasomal cleavage probability  peptide origin  peptide processing 
GenomicsRibosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance
Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance
PRJNA471521 | ENA
TranscriptomicsRibosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance
The MHC class I antigen presentation system enables T cell immunosurveillance of cancers and viruses. Rapidly degraded nascent polypeptides (DRiPs) provide many class I peptide ligands. By knocking down each of the 80 ribosomal proteins, we identified proteins that modulate peptide generation withou...
ORGANISM(S): Homo sapiens 
2019-01-21 | GSE114484 | GEO
UnknownInvariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.
Not available
S-EPMC3461304 | biostudies-literature
UnknownThe human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing.
Not available
S-EPMC8118558 | biostudies-literature
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