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Circadian rhythms are responsive to a variety of external cues, light and metabolism being the most important. In mammals, the light signal is sensed by the retina and transmitted to the SCN master clock, where it is translated into the molecular oscillator via regulation of clock gene transcription...
ORGANISM(S): Mus musculus 
We aimed to fill the gap in understanding functional roles of the islet cellular oscillators under diabetic conditions following massive β-cell ablation, and during β-cell regeneration. We assessed diurnal regulation of β-cell proliferation and transcriptional landscape in separated α- and residual ...
ORGANISM(S): Mus musculus 
2020-10-01 | GSE151338 | GEO
Circadian (~24 hour) clocks exist in almost all types of living organism and play a fundamental role in regulating daily physiological and behavioural processes. The transcription factor BMAL1 (ARNTL) is thought to be one of the principal drivers of the molecular clock in mammals since its deletion ...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD009243 | Pride
RNA-seq analysis in residual pancreatic β-cells of Bmal1KO/DTA mice following massive ablation
Plant hypocotyls elongate in response to darkness. The response to darkness is gated by the circadian clock, such that wild-type plants (Col) only respond to darkness with growth once every 24 hours, whereas arrhythmic lines, such as CCA1-34, will respond to darkness with growth at any time of day....
ORGANISM(S): Arabidopsis thaliana 
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