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MetabolomicsEllagic Acid Alleviates Colitis by Inhibiting Ferroptosis via Nrf2/GPX4 Signaling

Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a key driver of intestinal epithelial injury in inflammatory bowel disease (IBD). The Nrf2–GPX4 signaling axis provides a critical defense against ferroptotic damage; however, its therapeutic modulation remains underexplo...

2025-12-19 | MTBLS13535 | MetaboLights
MetabolomicsFOXA2 controls the anti-oxidant response in FH-deficient cells independent of NRF2
Not available
ORGANISM(S): Mus musculus 
ST002199 | MetabolomicsWorkbench
MetabolomicsArtemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in osteoporosis mice via the Nrf2/SLC7A11/GPX4 pathway

With the aging of the population, the incidence of postmenopausal osteoporosis (PMOP) is increasing. Artemisiae Scopariae Herba (Yinchen, YC) extracts have been reported to promote osteogenic differentiation and bone formation, but the specific mechanism is ...

2025-09-26 | MTBLS13042 | MetaboLights
TranscriptomicsTranscription profiling of livers and spleens from Nrf2 knockout mice and wildtype mice to measure differential gene expression.
In situ synthesized oligo arrays, U74Av2, from Affymetrix were used to measure differential gene expression in RNA samples generated from the liver (GSE864) and spleen (GSE865) of Nrf2 knockout and wildtype mice at 5 months of age. This SuperSeries is composed of the following subset Series:; GSE864...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-867 | biostudies-arrayexpress
TranscriptomicsCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors the activity of Nrf2 is inhibited by its interaction with the kelch-like ECH-associated protei...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-71695 | biostudies-arrayexpress
GenomicsNrf2 bindng in C2C12 myotubes
Nrf2 (NF-E2-related-factor-2) contributes to the maintenance of glucose homeostasis in vivo. Nrf2 suppresses blood glucose levels by protecting pancreatic β-cells from oxidative stress and improving peripheral tissue glucose utilization. To elucidate the molecular mechanisms by which Nrf2 contribut...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-78780 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of A549 cell treated with NRF2 siRNA and control siRNA
To examine the role of NRF2 in accelerating cell proliferation and to identify the target genes responsible for this function, transcriptome analysis was performed using A549 cells, in which NRF2 is constitutively activated. NRF2 was knocked down by siRNA against NRF2, and the gene expression profil...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-28230 | biostudies-arrayexpress
GenomicsComparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent [ChIP-Seq]
Nrf2(A502Y) mutant macrophages Nrf2(AY/AY) macrophages were more susceptible to toxicity of xenobiotics. To confirm preferences of binding sequences of Nrf2 and Nrf2A502Y in vivo, we performed ChIP-Seq analyses using an anti-Nrf2 antibody on the DEM-treated peritoneal macrophages derived from Nrf2+/...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-75175 | biostudies-arrayexpress
TranscriptomicsCoordinate Control of Nrf2 Mediated Genes in the Human Small Airway Epithelium Highly Responsive to Smoking
Nuclear factor erythroid 2-related factor 2 (NFE2L2, Nrf2) is an oxidant responsive transcription factor known to induce phase 2 detoxifying and antioxidant genes to protect cells from oxidative stress. Cigarette smoke, with its large oxidant content, is a major stressor to the small airway epitheli...
ORGANISM(S): Homo sapiens 
2009-07-13 | E-GEOD-11952 | biostudies-arrayexpress
GenomicsIdentification of Novel NRF2-Regulated Genes by ChIPSeq
Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to DNA-regulatory sequences near stress responsive genes. Studies using Nrf2-deficient mice suggest that hundreds of genes may be regula...
ORGANISM(S): Homo sapiens 
2012-06-18 | E-GEOD-37589 | biostudies-arrayexpress
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