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MetabolomicsEllagic Acid Alleviates Colitis by Inhibiting Ferroptosis via Nrf2/GPX4 Signaling

Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a key driver of intestinal epithelial injury in inflammatory bowel disease (IBD). The Nrf2–GPX4 signaling axis provides a critical defense against ferroptotic damage; however, its therapeutic modulation remains underexplo...

2025-12-19 | MTBLS13535 | MetaboLights
MetabolomicsArtemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in osteoporosis mice via the Nrf2/SLC7A11/GPX4 pathway

With the aging of the population, the incidence of postmenopausal osteoporosis (PMOP) is increasing. Artemisiae Scopariae Herba (Yinchen, YC) extracts have been reported to promote osteogenic differentiation and bone formation, but the specific mechanism is ...

2025-09-26 | MTBLS13042 | MetaboLights
TranscriptomicsCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors the activity of Nrf2 is inhibited by its interaction with the kelch-like ECH-associated protei...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-71695 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers and spleens from Nrf2 knockout mice and wildtype mice to measure differential gene expression.
In situ synthesized oligo arrays, U74Av2, from Affymetrix were used to measure differential gene expression in RNA samples generated from the liver (GSE864) and spleen (GSE865) of Nrf2 knockout and wildtype mice at 5 months of age. This SuperSeries is composed of the following subset Series:; GSE864...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-867 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of A549 cell treated with NRF2 siRNA and control siRNA
To examine the role of NRF2 in accelerating cell proliferation and to identify the target genes responsible for this function, transcriptome analysis was performed using A549 cells, in which NRF2 is constitutively activated. NRF2 was knocked down by siRNA against NRF2, and the gene expression profil...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-28230 | biostudies-arrayexpress
TranscriptomicsCoordinate Control of Nrf2 Mediated Genes in the Human Small Airway Epithelium Highly Responsive to Smoking
Nuclear factor erythroid 2-related factor 2 (NFE2L2, Nrf2) is an oxidant responsive transcription factor known to induce phase 2 detoxifying and antioxidant genes to protect cells from oxidative stress. Cigarette smoke, with its large oxidant content, is a major stressor to the small airway epitheli...
ORGANISM(S): Homo sapiens 
2009-07-13 | E-GEOD-11952 | biostudies-arrayexpress
TranscriptomicsIdentification of Nrf2-regulated genes in A549 lung cancer cells by oligonucleotide microarray
To elucidate the mechanisms by which Nrf2 regulates cell growth, we performed global gene expression profiling of A549 lung cancer cells with knockdown of Nrf2. Gene networks associated with carbohydrate metabolism and drug metabolism were significantly downregulated in Nrf2-depleted A549 cells. Gen...
ORGANISM(S): Homo sapiens 
2013-07-04 | E-GEOD-38332 | biostudies-arrayexpress
TranscriptomicsEffect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol. The purpose of this study was to investigate the rol...
ORGANISM(S): Mus musculus 
2014-02-18 | E-GEOD-55001 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of the cytoprotective transcription factor Nrf2 in skin morphogenesis and disease: Identification of Nrf2 target genes
The Nrf2 transcription factor is a key player in the cellular stress response, which regulates the expression of important antioxidant enzymes and other cytoprotective proteins. We recently generated a novel transgenic mouse model to determine the function of Nrf2 in the skin. These mice revealed in...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-35160 | biostudies-arrayexpress
Proteomics,MultiomicsElectrophilic stress induced by itaconate and its derivatives regulates ATF3-IKBZ inflammatory axis independently of Nrf2 induction
Metabolic regulation recently emerged as a novel powerful principle guiding immune responses. The natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) were recently shown to selectively inhibit a subset of cytokines during macrophage activation, yet the precise ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-25 | MSV000082101 | MassIVE
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