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GenomicsNucleoporin Nup153 Regulates Stem Cell Pluripotency through Gene Silencing
Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), the transport channels that mediate nuclear transport. Recent evidence suggest that several Nups have additional roles in controlling the activation and silencing of developme...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-64008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NUP98-NSD1 transformed samples reveals NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. INCOMPLETE DATASET
Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, multiple myeloma and lung cancers. ...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10071 | biostudies-arrayexpress
GenomicsDeletion of nucleoporin Seh1 impaired neurogenesis through transcriptional regulation (ChIP-Seq)
Deletion of nucleoporin Seh1 impaired neurogenesis through transcriptional regulation (ChIP-Seq)
PRJNA976911 | ENA
UnknownAltered localization of nucleoporin 98 in primary tauopathies.
Not available
S-EPMC9806717 | biostudies-literature
GenomicsNucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
PRJNA846167 | ENA
GenomicsDeletion of nucleoporin Seh1 impaired neurogenesis through transcriptional regulation (ChIP-Seq)
Nucleoporin Seh1 and chromodomain helicase DNA binding protein 4 have been involved in gene regulation. To dissect direct regulated genes, we performed chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for nucleoporin Seh1 or chromodomain helicase DNA binding protein 4 in neural stem cells.
ORGANISM(S): Mus musculus 
2023-05-29 | GSE233613 | GEO
ProteomicsSMAD nucleocytoplasmic shuttling relies on nucleoporin RanBP2 and VIM-AS1 long non-coding RNA during TGF-β signaling
Activation of the transforming growth factor β (TGF-β) signaling leads to established hallmarks of cancer such as the epithelial-to-mesenchymal transition (EMT), initiating cancer dissemination and increasing chemoresistance. TGF-β signal by binding to its type I and II receptors, leading to paralle...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD057186 | Pride
Cancer  epithelial-to-mesenchymal transition  long non-coding rna  nucleoporin  smad  transforming growth factor β  vim-as1 
GenomicsNucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
Nucleoporin Seh1 has been involved in gene regulation. To dissect nucleoporin's direct regulated genes, we performed chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for nucleoporin Seh1 in neural stem cells.
ORGANISM(S): Mus musculus 
2022-06-09 | GSE205508 | GEO
ProteomicsAnalysis of the Putative Nucleoporin POM33 in the Filamentous Fungus Sordaria macrospora
The POM33 protein of Sordaria macrospora is a nucleoporin considered of being an ER-protein that may function in ER-shaping and organization. In this study, we performed TagRFP-T pulldown experiments in S. macrospora strains expressing either POM33-TagRFP-T or the free TagRFP-T as control to identif...
ORGANISM(S): Sordaria macrospora 
2021-08-23 | PXD026253 | Pride
Stripak Sordaria macrospora. pom33 Endoplasmatic reticulum 
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