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GenomicsMLL1 is essential for the senescence-associated secretory phenotype [ChIP-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78141 | biostudies-arrayexpress
TranscriptomicsMLL1 is essential for the senescence-associated secretory phenotype [RNA-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78138 | biostudies-arrayexpress
GenomicsMLL1 is essential for the senescence-associated secretory phenotype
This SuperSeries is composed of the SubSeries listed below. Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory respon...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-78142 | biostudies-arrayexpress
GenomicsLamin B1 ChIPseq experiments from ER:RAS IMR90s
Lamin B1 from OIS IMR90s We used ChIP-seq to examine the global binding of Lamin B1 in human IMR90 oncogene-induced senescence
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-53331 | biostudies-arrayexpress
GenomicsH3K9me3 ChIPseq experiments from PD IMR90s
H3K9me3 ChIPseq in Proliferating and Senescent IMR90s We used ChIP-seq to examine the global binding of H3K9me3 in human IMR90 replicative senescence (RS) and oncogene-induced (OIS)
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-53329 | biostudies-arrayexpress
GenomicsSingle cell RNAseq of control vs. OIS hepatocytes
Single cell RNAseq of control vs. OIS hepatocytes
PRJNA919039 | ENA
TranscriptomicsTranscription profiling of human BRAFE600-expressing, senescent fibroblast cells that have bypassed oncogene-induced senescence by depletion of C/EBPb a
Analysis of BRAFE600-expressing, senescent cells, and bypass from OIS by depletion of C/EBPb and IL-6
ORGANISM(S): Homo sapiens 
2008-06-13 | E-NCMF-13 | biostudies-arrayexpress
GenomicsEffect of NAMPT modulation in OIS-senescent IMR90 cells
Effect of NAMPT modulation in OIS-senescent IMR90 cells
PRJNA1481531 | ENA
ProteomicsPhosphoproteome dynamics in onset and maintenance of Oncogene-Induced Senescence, proteome dataset
Expression of the BRAFV600E oncoprotein is known to cause benign lesions, for example melanocytic nevi (moles). In spite of the oncogenic function of mutant BRAF, these lesions are arrested by a cell-autonomous mechanism called Oncogene-Induced Senescence (OIS). Infrequently, nevi can progress to ma...
ORGANISM(S): Homo sapiens (Human) 
2015-01-13 | PXD001068 | Pride
Cancer Phosphoproteome Proteome Oncogene-induced senescence 
ProteomicsPhosphoproteome dynamics in onset and maintenance of Oncogene-Induced Senescence, phosphoproteome dataset
Expression of the BRAFV600E oncoprotein is known to cause benign lesions, for example melanocytic nevi (moles). In spite of the oncogenic function of mutant BRAF, these lesions are arrested by a cell-autonomous mechanism called Oncogene-Induced Senescence (OIS). Infrequently, nevi can progress to ma...
ORGANISM(S): Homo sapiens (Human) 
2015-01-12 | PXD000523 | Pride
Human fibroblasts 
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