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MetabolomicsAlterations in the oral microbiome and metabolome of methamphetamine addicts

BACKGROUND: Drug addiction can seriously damage human physical and mental health, while detoxification is a long and difficult process. Although studies have reported changes in the oral microbiome of methamphetamine (METH) addicts, the role of the microbiome plays in this proces...

2023-07-24 | MTBLS7807 | MetaboLights
MetabolomicsOral dysbiosis initiates periodontal disease in experimental kidney disease

BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...

2025-09-04 | MTBLS1833 | MetaboLights
MetabolomicsLong-lasting effects of oral polysaccharides on chemotherapy efficacy via alteration of the gut microbiota in a mouse model

Gemcitabine always has a short-term immune effect, and we consider using oral polysaccharides to lengthen its immune effect by modulating gut microbiotas. To verify this, we built a breast cancer mice model in situ, oral polysaccharides and a low-dose of Gemcitabine were administrated, ...

2025-06-14 | MTBLS12563 | MetaboLights
MetabolomicsExploring the Impact of Sleep Deprivation on the Characteristics and Associations of Oral-Gut Microbiota in Adolescents with Comorbidity of Dental Caries and Obesity
We conducted a cross-sectional study involving 85 adolescents aged 12–15 years, divided into healthy controls (HC), caries-obesity comorbidity (CO), and caries-obesity with sleep deprivation (COS) groups. Oral and fecal samples were collected for 16S rRNA gene sequencing, untargeted metabolomics, an...
2026-04-29 | MTBLS14395 | MetaboLights
MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
MetabolomicsImpact of oral Chlamydia Vaccination on Host Gut Microbiome and Metabolite Composition

Chlamydia trachomatis, an intracellular pathogen, is recognized as the most common sexually transmitted bacterial infection among women worldwide. Chlamydia infections can lead to undesirable clinical outcomes, including pelvic inflammatory disease and infertility. Recently, the gut has been...

2025-11-07 | MTBLS12603 | MetaboLights
MetabolomicsOral Engineered Microalgae- Biosystem Targeting Intestinal Villi for Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is a chronic gastrointestinal disorder associated with dysregulation of the gut-brain axis. Current treatment approaches often lack long-term efficacy and target specificity, and there are no drugs or formulations specifically targeting this disease. Owing to chronic a...
2025-07-18 | MTBLS12537 | MetaboLights
GenomicsSaliva microbiota in Finnish children
The human intestinal microbiota may play a role in the development of overweight and obesity. However, associations between saliva microbiota and body mass index (BMI) have been sparsely studied, although the oral cavity is the major gateway for microbes into the body. The aim of this study was to i...
EGAS00001003039 | EGA
MetabolomicsExploring the Influence of Psychological Factors on the Comorbidity of Dental Caries and Obesity in Adolescents from the Perspective of the Oral-Gut-Brain Axis

This study explores the impact of psychological factors on the comorbidity of dental caries and obesity in adolescents through the oral-gut-brain axis. An epidemiological survey was conducted on 1,024 students from Beizhen No. 1 Junior High School, with 90 adolescents aged 12–15 included in biosa...

2025-08-22 | MTBLS12873 | MetaboLights
MetabolomicsOral-gut microbiome and plasma metabolome reveal incremental restratification of coronary artery disease from the clinical gray zone
Clinical prediction models have been widely applied for risk stratification of coronary artery disease (CAD), yet approximately 20% to 40% of screened individuals fall into the intermediate-risk interval and face a decision gap. Here, we adopted a two-stage validation design. In the first stage, a c...
2026-08-31 | MTBLS15425 | MetaboLights
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