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MetabolomicsPaeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and its Metabolites

BACKGROUND: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the gastrointestinal tract. Recent studies demonstrate that the phenolic tannin paeonol (Pae) attenuates UC in mouse models by downregulating inflammatory factors; however, molecular mechanisms lin...

2024-09-27 | MTBLS5204 | MetaboLights
ProteomicsCharacterization of novel a-Mangostin and Paeonol derivatives with cancer-selective cytotoxicity
a-Mangostin and Paeonol have shown anti-cancer and anti-inflammatory properties, however these two natural compounds have no clinical value because of their low solubility and low membrane permeability. In this study, we screened chemically synthesized derivatives from these two natural compounds as...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024999 | Pride
Colorectal cancer  anti-cancer drugs  cancer-selective compounds  natural compound derivatives  colon cancer organoids  paeonol  a-mangostin 
TranscriptomicsPaeonol Alleviates Skin Inflammation and Pruritus in Atopic Dermatitis by Inhibiting the TRPV3/NF-κB/CCL3 Axis of Keratinocytes
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous lesions and intense pruritus. Skin inflammation mediated by transient receptor potential vanillin 3 (TRPV3) in keratinocytes is a key mechanism driving the progression of AD. Paeonol is a bioactive ...
ORGANISM(S): Mus musculus 
2025-12-01 | GSE289250 | GEO
GenomicsRNA sequencing of ovarian cancer cells treated by Paeonol
RNA sequencing of ovarian cancer cells treated by Paeonol
PRJNA802126 | ENA
GenomicsPaeonol Alleviates Skin Inflammation and Pruritus in Atopic Dermatitis by Inhibiting the TRPV3/NF-κB/CCL3 Axis of Keratinocytes
Paeonol Alleviates Skin Inflammation and Pruritus in Atopic Dermatitis by Inhibiting the TRPV3/NF-κB/CCL3 Axis of Keratinocytes
PRJNA1221997 | ENA
UnknownPaeonol attenuates inflammation by confining HMGB1 to the nucleus.
Not available
S-EPMC7957162 | biostudies-literature
UnknownSelf-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol.
Not available
S-EPMC4632989 | biostudies-literature
UnknownAttenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice.
Not available
S-EPMC4856301 | biostudies-literature
UnknownPaeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p.
Not available
S-EPMC6920373 | biostudies-literature
UnknownPaeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis.
Not available
S-EPMC8718120 | biostudies-literature
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