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TranscriptomicsGenome wide analysis of pancreatic cancer cell gene expresison exposed to stromal pancreatic stellate cells in 3D gel matrix
Capan1 (well differentiated pancreatic cancer cell line) was co-cultured with pancreatic stellate cell line (PS1) embedded in a 3D organotypic model and gene expression was analysed in comparison to cancer cells cultured alone without stellate cells. Pancreatic stellate cells were embedded within a ...
ORGANISM(S): Homo sapiens 
2013-03-23 | E-GEOD-36775 | biostudies-arrayexpress
TranscriptomicsRole of Macrophage migration inhibitory factor (MIF) in pancreatic stellate cells (PSCs)
The presence of activated pancreatic stellate cells (PSCs) in the pancreatic ductal adenocarcinoma (PDAC) microenvironment plays a significant role in cancer progression. Macrophage migration inhibitory factor (MIF) is overexpressed in PDAC tissues and expressed by both cancer and stromal cells. The...
ORGANISM(S): Mus musculus 
2022-09-28 | E-MTAB-9392 | biostudies-arrayexpress
ProteomicsA comparative proteomics analysis identified differentially expressed proteins in pancreatic cancer–associated stellate cell small extracellular vesicles
Human pancreatic stellate cells (HPSCs) are an essential stromal component and are the mediators of pancreatic ductal adenocarcinoma (PDAC) progression. Small extracellular vesicles (sEVs) are membrane-enclosed nanoparticles released from stellate cells adjacent to the PDAC. sEVs are believed to pla...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD030077 | Pride
Exosomes Human Stellate cells Pancreatic cancer 
TranscriptomicsRNA-Seq of isolated pancreatic stellate cells from mice with autoimmune pancreatitis and chronic pancreatitis
Autoimmune pancreatitis (AIP) is a disease with unclear immunologic triggers. This study shows that the pancreatic stellate cells(PSCs) are involved in the regulation of the immune response and can cause autoimmunity when the NF-κB signalling in these cells is disrupted. The PSCs were isolated from ...
ORGANISM(S): Mus musculus 
2023-06-30 | E-MTAB-7337 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hepatic and pancreatic stellate cells obtained from tissues of chronic inflammation, and primary or metastatic cancers
Differences in the expression profile of hepatic and pancreatic stellate cells are investigated. Aim is to identify organ and disease specific transcriptome signatures of stellate cells, comparing hepatic and pancreatic stellate cells obtained from tissues of chronic inflammation, and primary or me...
ORGANISM(S): Homo sapiens 
2010-01-15 | E-TABM-625 | biostudies-arrayexpress
TranscriptomicsExpression data from pancreatic stellate cells
tumor-stroma crosstalk drives pancreatic carcinogenesis we used time-resolved genome-wide transcriptional profiling to analyse changes caused by co-exposure of pancreatic tumor and stellate cells Primary pancreatic Stellate cells (PSC) were treated with a cumulative supernatant of pancreatic tumor ...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-49583 | biostudies-arrayexpress
GenomicsCirculating pancreatic stellate cells: a new window into pancreatic cancer metastasis
Circulating pancreatic stellate cells: a new window into pancreatic cancer metastasis
PRJNA734013 | ENA
TranscriptomicsVitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) has been attributed to intrinsic resistance to chemotherapy and a growth-permissive tumor microenvironment. Quiescent pancreatic stellate cells (PSCs) are neuroendocrine, nestin-positive, lipid-accumulating cells whose homologues i...
ORGANISM(S): Mus musculus 
2014-10-03 | E-GEOD-43770 | biostudies-arrayexpress
ProteomicsEstablishment of pancreatic cancer cells spectral library based on data-independent acquisition strategy and the phenotype analysis of pancreatic cell lines of the sensitivity and resistance of gemcitabine
Based on data-independent acquisition (DIA)-mass spectrometry (MS) proteomics, we first established a high-coverage human pancreatic cells spectrum library. Furthermore, analyzed the sensitivity and drug resistance phenotypes to gemcitabine (GEM).
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD031028 | Pride
Pancreas Gem Emt Data independent acquisition Data dependent acquisition 
ProteomicsNADPH Oxidase 1 in Chronic Pancreatitis-Activated Pancreatic Stellate Cells Facilitates the Progression of Pancreatic Cancer
Aims: Patients suffering from chronic pancreatitis (CP) have a higher risk of pancreatic ductal adenocarcinoma (PDAC). NADPH oxidase 1 (Nox1) in activated pancreatic stellate cells from a CP mouse model (CP-activated PaSCs) forms fibrotic tissue and up-regulates matrix metalloproteinase (MMP) 9. Yet...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD034177 | Pride
Nadph oxidase 1  mmp-9  peroxiredoxin  twist1  p38 mapk  pancreatic stellate cells 
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