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MetabolomicsAppropriate taxonomic classification of intestinal microbiome by 16S rRNA gene targeting metagenomic approach
16S metagenomic analysis has provided much information about the intestinal microbiome. However, there are no reports that describe their appropriate taxonomic classification rank. Moreover, studies differ on the taxonomic ranking of the same microorganism. Intestinal microbiome exerts a significant...
2017-02-20 | MTBLS376 | MetaboLights
MetabolomicsTargeting secreted MDK-mediated tryptophan/kynurenine metabolism enhances DLL3 CAR T therapy for SCLC

Small cell lung cancer (SCLC) exhibits profound immunometabolic suppression that impairs antigen presentation and constrains immunotherapy efficacy. Through integrated multi-omics analyses of primary human SCLC tumors, we identified midkine (MDK) as a dominant tumor-secreted driver of immune evas...

2026-03-23 | MTBLS14116 | MetaboLights
UnknownDevelopment and Application of a Novel Model System to Study "Active" and "Passive" Tumor Targeting.
Not available
S-EPMC5050124 | biostudies-literature
UnknownPassive immunotherapies targeting Aβ and tau in Alzheimer's disease.
Not available
S-EPMC7365083 | biostudies-literature
UnknownPotent cancer therapy by liposome microstructure tailoring with active-to-passive targeting and shell-to-core thermosensitive features.
Not available
S-EPMC10995888 | biostudies-literature
TranscriptomicsA variety of Dicer substrates in human and C. elegans (HEK PAR-CLIP)
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been directly mapped. Here, we apply biochemical methods to human cells and C. elegans and identify thousands of Dicer binding site...
ORGANISM(S): Homo sapiens 
2014-11-20 | E-GEOD-63437 | biostudies-arrayexpress
ProteomicsNew insights into hypoxia-driven metabolic, anti-apoptotic and immune evasion strategies of primary human myeloma cells
Multiple Myeloma (MM) is an incurable plasma cell malignancy primarily localized within the bone marrow (BM). It develops from a premalignant stage, monoclonal gammopathy of undetermined significance (MGUS), often via an intermediate stage, smoldering MM (SMM). The mechanisms of MM progression have ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-17 | MSV000084470 | MassIVE
UnknownPassive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats.
Not available
S-EPMC8241188 | biostudies-literature
TranscriptomicsA variety of Dicer substrates in human and C. elegans (CEL RNA-seq)
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been directly mapped. Here, we apply biochemical methods to human cells and C. elegans and identify thousands of Dicer binding site...
ORGANISM(S): Caenorhabditis elegans 
2014-11-20 | E-GEOD-63435 | biostudies-arrayexpress
UnknownCharacterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging.
Not available
S-EPMC4031451 | biostudies-literature
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