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ProteomicsPCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina
Inherited retinal dystrophies (IRDs) are a group of debilitating visual disorders characterized by the progressive degeneration of photoreceptors, which ultimately lead to blindness. Among the causes of this condition, mutations in the PCYT1A gene, which encodes the rate-limiting enzyme responsible ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD051537 | Pride
Irds  pcyt1a  fatty acid metabolism  ferroptosis 
UnknownPCYT1A Missense Variant in Vizslas with Disproportionate Dwarfism.
Not available
S-EPMC9777673 | biostudies-literature
UnknownEarly embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a).
Not available
S-EPMC1069620 | biostudies-literature
GenomicsExpression data from intestine samples of mice lacking intestinal Pcyt1a, which encodes an enzyme that regulates phosphatidylcholine synthesis.
Expression data from intestine samples of mice lacking intestinal Pcyt1a, which encodes an enzyme that regulates phosphatidylcholine synthesis.
PRJNA433833 | ENA
GenomicsExpression data from intestine samples of mice lacking intestinal Pcyt1a, which encodes an enzyme that reguates phosphatidylcholine synthesis.
Expression data from intestine samples of mice lacking intestinal Pcyt1a, which encodes an enzyme that reguates phosphatidylcholine synthesis.
PRJNA532759 | ENA
UnknownMutations in the PCYT1A gene are responsible for isolated forms of retinal dystrophy.
Not available
S-EPMC5392360 | biostudies-literature
UnknownPCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.
Not available
S-EPMC5971203 | biostudies-literature
UnknownMutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy.
Not available
S-EPMC3882913 | biostudies-literature
ProteomicsMechanistic study of SENP2-PCYT1A axis regulating synaptic pruning that results in anxiety-like behavior
Anxiety disorder, one of the most common mental illnesses, is emerging as a significant public health challenge. Glial regulation of neuronal synaptic pruning offers a novel therapeutic avenue for anxiety; however, it remains unclear whether SUMO modification is involved in this regulatory process. ...
ORGANISM(S): Mus Musculus 
2026-06-23 | PXD080104 |
UnknownMYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma.
Not available
S-EPMC5549253 | biostudies-literature
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