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MetabolomicsIntegrated multi-omics of feces, plasm aand urine can describe and differentiate pediatric active Crohn’s Disease from remission

Background

This study aimed to obtain a holistic view of remission in pediatric Crohn’s Disease (CD) by integrating six omics datasets from three anatomical compartments.


Methods

Patients with fecal calprotectin below 250 mg/kg were c...

2025-07-09 | MTBLS9877 | MetaboLights
GenomicsIFNg Signature in Plasma Proteome Distinguishes Pediatric Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS
IFNg Signature in Plasma Proteome Distinguishes Pediatric Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS
PRJNA633278 | ENA
UnknownDefining the Inflammatory Plasma Proteome in Pediatric Hodgkin Lymphoma.
Not available
S-EPMC7761312 | biostudies-literature
ProteomicsOntology-guided clustering enables proteomic analysis of rare pediatric disorders
The study of rare pediatric disorders is fundamentally limited by small patient numbers, making it challenging to draw meaningful conclusions about their molecular basis. To address this, we developed a framework that integrates clinical ontologies with proteomic profiling, enabling the systematic a...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD058960 | Pride
Pediatrics / plasma / proteomics / snomed ct / urine 
UnknownPlasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition.
Not available
S-EPMC12483069 | biostudies-literature
ProteomicsAnalysis of proteolytic processes in plasma and bone marrow interstitial fluid of pediatric B-ALL patients by HUNTER (High-efficiency Undecanal-based N Termini EnRichment)
Protein N-termini reveal fundamental regulatory mechanisms and their perturbation in disease. We present a robust, sensitive, scalable and automatable method called High-efficiency Undecanal-based N Termini EnRichment (HUNTER) for system-wide identification of thousands of N-termini from minute samp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-02-28 | MSV000083502 | MassIVE
UnknownTemporal profiles of plasma proteome during childhood development.
Not available
S-EPMC5219852 | biostudies-literature
TranscriptomicsIFNg Signature in Plasma Proteome Distinguishes Pediatric Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS
Expression data from CD8+ T cells and CD68+ monocytes from patients with hemophagocytic lymphohistiocytosis, sepsis, and persistent systemic inflammatory response syndrome Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by pathologic immune activation in which prompt recognition...
ORGANISM(S): Homo sapiens 
2021-05-16 | GSE150707 | GEO
UnknownIFN-γ signature in the plasma proteome distinguishes pediatric hemophagocytic lymphohistiocytosis from sepsis and SIRS.
Not available
S-EPMC8525230 | biostudies-literature
ProteomicsTemporal Expression Profiling of Plasma Proteins in Type 1 Diabetes Progression
A longitudinal proteomic profiling of human plasma using TMT-10plex-based LC-MS/MS analysis was performed to track temporal proteomic changes of T1D patients (n = 11) across 9 serial time points, spanning the period of T1D natural progression, in comparison with those of the matching healthy control...
ORGANISM(S): Homo sapiens (Human) 
2018-03-08 | PXD007884 | Pride
Temporal proteome change  type 1 diabetes  tmt10  pediatric plasma proteome  longitudinal profiling 
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