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MetabolomicsMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NR...
2021-06-22 | MTBLS2313 | MetaboLights
MetabolomicsPlant elicitor peptide signalling confers rice resistance to piercing-sucking insect herbivores and pathogens
Rice is a staple food crop worldwide, and its production is severely threatened by phloem-feeding insect herbivores, particularly the brown planthopper (BPH, Nilaparvata lugens), and destructive pathogens. Despite the identification of many BPH resistance genes, the molecular basis of rice resistanc...
2022-02-23 | MTBLS3518 | MetaboLights
MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
MetabolomicsDivalent Aptamer-mediated Clustering for Extracellular Vesicle Separation
Extracellular vesicles (EVs) are important mediators of intercellular communication and promising sources of diagnostic and therapeutic biomarkers, yet effective EV isolation remains challenging due to trade-offs among yield, purity, and adaptability across biofluids. Here, we introduce divalent apt...
2026-05-04 | MTBLS14425 | MetaboLights
ProteomicsAutoimmune peptide antigen reactivity in BXD2 mice with spontaneous systemic autoimmune disease
The aim of the study was to determine autoimmune BXD2 mouse sera reactivity to linear peptide epitopes from the Immune Epitope Database. Pooled sera from six 8-10 month old BXD2 mice was diluted at 1:1000 and incubated on a PEPperPRINT peptide microarray platform printed with peptide autoantigens. ...
ORGANISM(S): Mus musculus 
2015-02-28 | E-GEOD-65276 | biostudies-arrayexpress
ProteomicsAutoimmune peptide antigen reactivity in normal B6 mice Pepperchip 2.0
The aim of the array was to determine the B6 mouse sera IgG and IgM reactivity profile to linear peptide epitopes. Pooled sera from three 6-9 month old B6 mice was diluted at 1:200 for IgG specific analysis or 1:1000 for IgM specific analysis and incubated on a PEPperPRINT peptide microarray platfo...
ORGANISM(S): Mus musculus 
2015-02-28 | E-GEOD-65277 | biostudies-arrayexpress
ProteomicsAutoimmune peptide antigen reactivity in BXD2 mice with spontaneous systemic autoimmune disease Pepperchip 2.0
The aim of the array was to determine the BXD2 mouse sera IgG and IgM reactivity profile to linear peptide epitopes. Pooled sera from three 6-9 month old BXD2 mice was diluted at 1:200 for IgG specific analysis or 1:1000 for IgM specific analysis and incubated on a PEPperPRINT peptide microarray pl...
ORGANISM(S): Mus musculus 
2015-02-28 | E-GEOD-65278 | biostudies-arrayexpress
ProteomicsLipid mediated–phase separation of AGO proteins on the ER controls nascent peptide ubiquitination
we sought to determine whether dmAGO1 and Ltn1 share common ubiquitinated nascent peptide targets. For this purpose, we performed the UBA bead-based immunoprecipitation followed by mass spec experiments to identify the ubiquitinated nascent peptide targets of dmAGO1 and Ltn1, respectively. In this a...
ORGANISM(S): Drosophila Melanogaster 
2022-02-18 | PXD031749 |
ProteomicsConfident identification of citrullination and carbamylation assisted by peptide retention time prediction
We used 2D-LC-MS/MS methods to examine the impact of the biologically important PTM citrullination and its analogue carbamylation on peptide retention. Three first-dimension separation systems were evaluated: high-pH, HILIC and SCX, with the instrument interface separation happening at low-pH RP for...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Sus Scrofa (ncbitaxon:9823) Gallus Gallus (ncbitaxon:9031) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000086214 | MassIVE
OtherIPG strip-based peptide fractionation for shotgun proteomics.
Data from ProteomeXchange, PXD ID: PXD002389. Experiment: Bibo_20130621_CHS_IEF_3-10linear_24slices, file: Bibo_20130621_CHS_IEF_3-10linear_24slices_20.mzml. Published as part of Methods Mol Biol. 2014;1156:67-77 . From the Abstract: {{i}} Efficient fractionation of peptides is an essential prerequ...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320016255 | GPMDB
Resource Reanalysis 
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