Sort   by:  
 Page size 
MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
ProteomicsIn serach of the pH limit of growth in halo-alkaliphilic cyanobacteria
We cultivated two halo-alkaliphilic cyanobacteria consortia in chemostats at pH 10.2-11.4. One consortium was dominated by Ca. Sodalinema alkaliphilum, the other by a species of Nodosilinea. These two cyanobacteria dominate natural communities in Canadian and Asian alkaline soda lakes. We show that ...
ORGANISM(S): Sodalinema sp. PMC 1182.19 Nodosilinea sp. ATA3-4Q-CV33 
2024-10-17 | PXD052563 | Pride
Halo-alkaliphilic cyanobacteria  chemostat  alkaline soda lakes  ph limit  extremophile  nodosilinea  ca. sodalinema alkaliphilum 
UnknownAmmonia sets limit to life and alters physiology independently of pH in Halomonas meridiana.
Not available
S-EPMC12137954 | biostudies-literature
UnknownIn search of the pH limit of growth in halo-alkaliphilic cyanobacteria.
Not available
S-EPMC11317126 | biostudies-literature
ProteomicsRevisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin.
Replicative senescence (RS) as a model has become the central focus of research into cellular aging in vitro. Despite decades of study, this process through which cells cease dividing is not fully understood in culture, and even much less so in vivo during development and with aging. Here, we revisi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028799 | Pride
Hayflick limit Proteomics 
TranscriptomicsKnockdown of Polyhomeotic in Drosophila Kc cells
In this experiment, we used RNAi targeting both copies of the gene polyhomeotic (ph-p and ph-d) to knockdown expression of this factor in Drosophila Kc167 cells. We observed substantial changes to the structure of genomic loci bound by Polycomb-group proteins as assayed by single-molecule based sup...
ORGANISM(S): Drosophila melanogaster 
2015-11-20 | E-GEOD-75060 | biostudies-arrayexpress
TranscriptomicsThe rat lncRNA and mRNA microarray analysis of the 6 samples from2-AAF/PH group and Diwu Yanggan capsule treatment group
In some previous studies, DWYG played key roles in improving immune-modulatory responses, ameliorating liver lesions, enhancing liver regeneration, virus-killing activities and HCC inhibition. It has been shown that liver injury caused by an array of factors, can significantly hinder the regenerativ...
ORGANISM(S): Mus musculus Rattus norvegicus 
2020-06-03 | GSE151614 | GEO
UnknownSynergy of Ionic and Dipolar Effects by Molecular Design for pH Sensing beyond the Nernstian Limit.
Not available
S-EPMC6974946 | biostudies-literature
UnknownSRpHi ratiometric pH biosensors for super-resolution microscopy.
Not available
S-EPMC5603529 | biostudies-literature
UnknownCarbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.
Not available
S-EPMC6162214 | biostudies-literature
Sort   by:  
 Page size