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MetabolomicsCholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria
Efficient clearance and recycling of dysfunctional mitochondria through the robust catabolic activity of lysosomes is essential for cellular health. However, how membrane lipids contribute to maintaining the degradative capacity of lysosomes remains poorly understood. Here, we show that cholesterol ...
2026-07-30 | MTBLS15181 | MetaboLights
Genomicsp53 mediates phospholipid headgroup scavenging [ChIP-seq]
p53 mediates phospholipid headgroup scavenging [ChIP-seq]
PRJNA1118321 | ENA
Genomicsp53 mediates phospholipid headgroup scavenging [RNA-seq]
p53 mediates phospholipid headgroup scavenging [RNA-seq]
PRJNA1118320 | ENA
UnknownEndocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway.
Not available
S-EPMC1751321 | biostudies-literature
Transcriptomicsp53 mediates phospholipid headgroup scavenging [RNA-seq]
A growing number of studies have shown that p53 modulates metabolic pathways to support diverse biological functions. Given that p53 is most widely known to act as a transcriptional activator, this raises the possibility that p53 transcriptional activity governs metabolic reprogramming. Here, we per...
ORGANISM(S): Mus musculus 
2025-11-17 | GSE268723 | GEO
Genomicsp53 mediates phospholipid headgroup scavenging [ChIP-seq]
A growing number of studies have shown that p53 modulates metabolic pathways to support diverse biological functions. Given that p53 is most widely known to act as a transcriptional activator, this raises the possibility that p53 transcriptional activity governs metabolic reprogramming. Here, we per...
ORGANISM(S): Mus musculus 
2025-11-17 | GSE268722 | GEO
UnknownThe phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane.
Not available
S-EPMC5170610 | biostudies-literature
TranscriptomicsEffect of the deletion of the genes involved in phospholipid synthesis pathway on gene expression (DKO)
Phospholipid and nucleotide syntheses are fundamental metabolic processes in eukaryotic organisms, with their dysregulation implicated in various disease states. However, the interplay between these pathways remains elusive. With genetic and metabolic analyses in the yeast S. cerevisiae, we elucidat...
ORGANISM(S): Saccharomyces cerevisiae 
2024-07-25 | GSE269277 | GEO
TranscriptomicsEffect of the deletion of the genes involved in phospholipid synthesis pathway on gene expression (PAH1 DGK1)
Phospholipid and nucleotide syntheses are fundamental metabolic processes in eukaryotic organisms, with their dysregulation implicated in various disease states. However, the interplay between these pathways remains elusive. With genetic and metabolic analyses in the yeast S. cerevisiae, we elucidat...
ORGANISM(S): Saccharomyces cerevisiae 
2024-07-25 | GSE269275 | GEO
GenomicsEffect of the deletion of the genes involved in phospholipid synthesis pathway on gene expression (DKO)
Effect of the deletion of the genes involved in phospholipid synthesis pathway on gene expression (DKO)
PRJNA1120864 | ENA
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