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ProteomicsThe Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence
Protein phosphatases are post-translational regulators of Toxoplasma gondii proliferation, tachyzoite-bradyzoite differentiation and pathogenesis. Here, we identify the putative protein phosphatase 6 (TgPP6) subunits of T. gondii and elucidate their role in the parasite lytic cycle. The putative cat...
ORGANISM(S): Toxoplasma gondii VEG 
2023-11-28 | PXD041907 | Pride
Toxoplasma gondii  phosphoprotein phosphatase 6 catalytic subunit  endodyogeny  cell division  phosphoproteomics  virulence Immunoprotection 
ProteomicsThe C. elegans ASPP homolog APE-1 is a junctional Protein Phosphatase 1 modulator
Protein samples were analyzed by Multidimensional Protein Identification Technology (MudPIT), as described previously. Briefly, precipitated proteins were resuspended in 30uL of 100mM Tris pH 8.5 with 8M urea to denature proteins. Cysteines were reduced and alkylated prior to digestion with recombi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Caenorhabditis Elegans (ncbitaxon:6239) 
2022-02-04 | MSV000088781 | MassIVE
TranscriptomicsMapping and characterization of promoter-binding sites of protein phosphatase 1
Protein phosphatase 1 (PP1) is a Ser/Thr phosphatase that has been implicated in many key cellular functions including transcriptional regulation. Due to its involvement these many processes, it becomes difficult to directly link PP1 to transcriptional regulation on the chromatin level as no direct ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-54170 | biostudies-arrayexpress
ProteomicsHeLa phosphoproteome regulated by PP2A related proteins
HeLa cells were treated with siRNAs of PP2A related proteins or with okadaic acid, in triplicates. Tryptic digests of extracted proteins were analyzed using a Q Exactive mass spectrometer, before and after TiO2 phosphopeptide enrichment. Data were searched with Mascot via Proteome Discoverer. For ph...
ORGANISM(S): Homo Sapiens (human) 
2020-02-19 | PXD016102 | JPOST Repository
TranscriptomicsExpression data from porcine cells infected with TGEV wild-type (rTGEV-wt) or mutant (rTGEV-delta7) coronaviruses
Innate immune response is the first line of antiviral defense resulting, in most cases, in pathogen clearance with minimal clinical consequences. Viruses have developed diverse strategies to evade innate immune response and to ensure their survival. Using transmissible gastroenteritis virus (TGEV) a...
ORGANISM(S): Sus scrofa 
2013-09-30 | E-GEOD-41756 | biostudies-arrayexpress
UnknownInducible protein degradation as a strategy to identify Phosphoprotein Phosphatase 6 substrates in RAS-mutant colorectal cancer cells.
Not available
S-EPMC10055397 | biostudies-literature
UnknownInducible Protein Degradation as a Strategy to Identify Phosphoprotein Phosphatase 6 Substrates in RAS-Mutant Colorectal Cancer Cells.
Not available
S-EPMC10400926 | biostudies-literature
TranscriptomicsTranscription profiling of human serum starvation cell lines for 24hrs, 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56
Study the effects of serum starvation for 24hrs on 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56.
ORGANISM(S): Homo sapiens 
2004-10-01 | E-MEXP-156 | biostudies-arrayexpress
ProteomicsAurora B opposes PP1 function in mitosis through phosphorylation of the conserved RVxF binding motif in PP1 regulatory proteins
Protein phosphatase 1 (PP1) is a highly conserved protein phosphatase that opposes the actions of a diverse set of Ser-Thr protein kinases by controlling the majority of serine-threonine (Ser-Thr) dephosphorylation reactions in eukaryotes. PP1 gains substrate specificity through binding to a large n...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-30 | MSV000082226 | MassIVE
ProteomicsA Protein Phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome
Most eukaryotic proteins are regulated by phosphorylation. Phosphoprotein phosphatases (PPPs) are the key serine/threonine phosphatases that regulate all essential signaling cascades. In particular, Protein Phosphatase 1 (PP1) dephosphorylates a predicted ~80% of all ser/thr phosphorylation sites. H...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-22 | MSV000094153 | MassIVE
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