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MetabolomicsPentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-03-22 | MTBLS14090 | MetaboLights
MetabolomicsPentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-04-13 | MTBLS14264 | MetaboLights
ProteomicsPathological and physiological cardiac hypertrophy
This project is the comparison of protein profiles for pathological and physiological mouse cardiac hypertrophy
ORGANISM(S): Mus musculus (Mouse) 
2018-07-30 | PXD010165 | Pride
Cardiac hypertrophy Lc-ms/ms 
TranscriptomicsTranscriptome analysis of mouse cardiac hypertrophy
RNA-Seq analysis of mouse cardiac transcriptome. Transverse aortic contraction was used to induce cardiac hypertrophy (TAC). To compare wild type and physiological cardiac hypertrophy 'Sendetary' (feeding mouse during 4 weeks) and 'Swim (exercise training to induce the cardiac hypertrophy) sample...
ORGANISM(S): Mus musculus 
2012-05-11 | E-MTAB-727 | biostudies-arrayexpress
TranscriptomicsmiRNA-99 family diverges physiological cardiac hypertrophy to pathological cardiac hypertrophy
Purpose: The physiological cardiac hypertrophy is an adaptive condition that does not associate with myocyte cell death while pathological hypertrophy is a maladaptive condition associated with myocyte cell death. Alpha-2 macroglobulin (α-2M) an acute phase protein induces cardiac hypertrophy via t...
ORGANISM(S): Rattus norvegicus 
2015-11-01 | E-GEOD-73597 | biostudies-arrayexpress
GenomicsGenome wide TFIIB binding during postnatal and pressure-induced cardiac hypertrophy
Purpose: To identify the differential TFIIB bindingl patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts Methods: Hearts were extracted from 1-2day old C57 mice, from mice subjecetd to Transaortic coarctation or adult mice. The hearts were sent to Ac...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-56813 | biostudies-arrayexpress
GenomicsTranscriptional regulation patterns revealed by high-resolution chromatin immunoprecipitation during cardiac hypertrophy
Purpose: To identify the differential transcriptional patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts Results: Our data revealed novel transcriptional patterns during cardiac growth conditions. The results showed that most of the essential genes ...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-50637 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy
We performed microarray analyses on RNA from mice with isoproterenol-induced cardiac hypertrophy and mice with exercise-induced physiological hypertrophy and identified 865 and 2,534 genes that were significantly altered in pathological and physiological cardiac hypertrophy models, respectively. Ex...
ORGANISM(S): Mus musculus 
2009-11-10 | E-GEOD-18801 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of callipyge lambs at the onset of muscle hypertrophy in : time course
The callipyge mutation causes postnatal muscle hypertrophy in heterozygous lambs that inherit a paternal callipyge allele (+/CLPG). Our hypothesis was that the up-regulation of one or both of the affected paternally expressed genes (DLK1 or PEG11) initiates changes in biochemical and physiological ...
ORGANISM(S): Ovis aries 
2008-11-07 | E-GEOD-5195 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart samples from animals with physiological or pathological cardiac hypertrophy
Dahl salt-sensitive (DS) rats were obtained from Harlan Sprague Dawley Laboratory at 5 weeks of age. At 6 weeks of age, physiologic cardiac hypertrophy was generated by a; vigorous daily exercise regimen for 6 weeks (e group). The exercise protocol is based on those described previously with modific...
ORGANISM(S): Rattus norvegicus 
2007-10-11 | E-GEOD-776 | biostudies-arrayexpress
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