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ProteomicsHigh-Throughput Acoustic FFPE Proteomics Reveals ATP5IF1-Associated Mitochondrial Remodeling in Acral Melanoma
Formalin-fixed, paraffin-embedded (FFPE) archives underpin dermatopathology and translational oncology, enabling clinically annotated melanoma cohorts, but cohort-scale proteomics remains limited by labor and variability in upstream processing. We established a plate-scale, acoustic FFPE proteomics ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD074156 | Pride
Ai-digital pathology  atp synthase inhibitor if1  adaptive focused acoustics  acral melanoma Oxidative phosphorylation  plate-scale ffpe proteomics 
ProteomicsClinical proteomics workflow for high quality quantitative proteome and PTM analysis of biologically relevant FFPE tissue samples
In recent years, the use of formalin-fixed paraffin-embedded (FFPE) tissues has increased within cancer research and clinical proteomics. However, the use of FFPE tissues can be demanding due to paraffin embedding and cross-links introduced by the formaldehyde. Here, we developed a workflow implemen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020157 | Pride
Cancer Suspension trapping Lung adenocarcinoma Mass spectrometry Clinical proteomics Lysine acetylation stoichiomtery Throughput Proteomics Tissue Isobaric labeling Tmt Ffpe Sample preparation S-trap 
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