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The objective was to identify the molecular mechanisms responsible for in vitro and in vivo efficacy of an anti-MYCN peptide nucleic acid on a preclinical model of alveolar rhabdomyosarcoma. Cells treated with a anti-MYCN PNA exhibit growth arrest and apoptosis, and in vivo tumor growth is blocked. ...
ORGANISM(S): Homo sapiens 
full scale PNA Raw sequence reads
Onestage PNA reactor Raw sequence reads
The screening of a previously reported fluorescein labelled 10,000 member PNA encoded peptide library allowed information on the interaction between the peptide-ligands and the cell surface receptors to be extracted, identified new peptide ligands for cell surface receptors, and gave crucial informa...
ORGANISM(S): Homo sapiens 
The incubation of a 10,000 member PNA-encoded peptide library with cells over-expressing the alpha(v)beta(3) and alpha(v)beta(5) integrins (D54) or CCR6 (HEK293T-CCR6) followed by microarray analysis allowed detailed information on the interaction between peptide-ligands and cell surface receptors t...
ORGANISM(S): Homo sapiens 
Pantoea sp. PNA 03-3 Genome sequencing and assembly
Pantoea sp. PNA 14-12 Genome sequencing and assembly
Comparison of three developmental stages (Early Log, PNA- metacyclics and Mouse lesion Derived Amastigotes) of L.major FV1.
ORGANISM(S): Leishmania major 
B cells were extracted from spleens of mice treated with PNA a-miR155 and vehicle treated mice either wild type or mir-155 deficient. All mice received LPS to induce mir155 expression.
ORGANISM(S): Mus musculus 
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