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ProteomicsIdentification of PNPase and RhlB binding proteins in Deinococcus radiodurans
8-oxo-7,8-dihydroguanine (8-oxoG) is a common RNA oxidation that has been implicated in carcinogenesis, neurodegeneration, and aging. Some? Many? RNA-binding proteins have shown binding preference for 8-oxoG modified RNA; such binding? can protect cells from oxidative stress. To date, the presence o...
ORGANISM(S): Deinococcus radiodurans ATCC 13939 
2022-07-09 | PXD028866 | Pride
8-oxo-7 8-dihydroguanine  rna oxidation  rna binding proteins  pnpase  rhlb  oxidative stress  deinococcus radiodurans  rna degradation 
TranscriptomicsTranscription profiling of Arabidopsis thaliana wild-type and pnp mutant plants with respect to their morphology, metabolite profiles, and transcriptomes
A prominent enzyme in organellar RNA metabolism is the exoribonuclease polynucleotide phosphorylase (PNPase), whose reversible activity is governed by the nucleotides diphosphate-inorganic phosphate ratio. In Chlamydomonas reinhardtii, PNPase regulates chloroplast transcript accumulation in response...
ORGANISM(S): Arabidopsis thaliana 
2009-09-18 | E-GEOD-18071 | biostudies-arrayexpress
GenomicsTranscriptional profiling of PNPase KO liver hepatocytes
Transcriptional profiling of PNPase KO liver hepatocytes
PRJNA430113 | ENA
GenomicsPNPase knockout results in mtDNA loss and an altered metabolic gene expression program
PNPase knockout results in mtDNA loss and an altered metabolic gene expression program
PRJNA437833 | ENA
TranscriptomicsTranscriptional profiling of PNPase KO liver hepatocytes
Transcriptional profiling of PNPase KO liver hepatocytes (HepKO) generated from Albumin-Cre/wt (liver-specific) Pnpt1 fl/fl C57BL/6J mice. Samples comparing liver hepatocyte PNPase KO (HepKO) cells to litter-, age-, and sex-matched wildtype hepatocyte control cells. The goal of this experiment was t...
ORGANISM(S): Mus musculus 
2018-05-03 | GSE109210 | GEO
GenomicsThe RNA-binding protein PNPase regulates biofilm formation and virulence in Listeria monocytogenes
The RNA-binding protein PNPase regulates biofilm formation and virulence in Listeria monocytogenes
PRJNA863648 | ENA
GenomicsHigh-throughput sequencing of RNA isolated by crosslinking immunoprecipitation with CsdA or PNPase in E.coli
High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation with CsdA or PNPase in E.coli
PRJNA1394967 | ENA
UnknownRNase E biomolecular condensates stimulate PNPase activity.
Not available
S-EPMC10412687 | biostudies-literature
TranscriptomicsHigh-throughput sequencing of RNA isolated by crosslinking immunoprecipitation with CsdA or PNPase in E.coli
Our results show the RNA transcripts in complex with the helicase CsdA or the exoribonuclease PNPase. We used CsdA or a catalytically inactive variant of PNPase (PNPase D492G) as bait to capture enriched substrates bound by the enzymes. Sequencing of RNA isolated by crosslinking immunoprecipitation ...
ORGANISM(S): Escherichia coli 
2026-07-16 | GSE315071 | GEO
TranscriptomicsPNPase knockout results in mtDNA loss and an altered metabolic gene expression program
Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and several human disorders. To reveal role(s) for PNPase in mitochondria, we established PNPase knockout (PKO) systems by first shifting culture conditions to ena...
ORGANISM(S): Mus musculus 
2018-05-01 | GSE111668 | GEO
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