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GenomicsAn essential role for the ultra-conserved poison exon of Tra2b in fertility in mice (RNA-seq)
An essential role for the ultra-conserved poison exon of Tra2b in fertility in mice (RNA-seq)
PRJNA984310 | ENA
GenomicsAn essential role for the ultra-conserved poison exon of Tra2b in fertility in mice (iCLIP-seq)
An essential role for the ultra-conserved poison exon of Tra2b in fertility in mice (iCLIP-seq)
PRJNA984309 | ENA
TranscriptomicsAn essential role for the ultra-conserved poison exon of Tra2b in fertility in mice (RNA-seq)
Alternative splicing-induced inclusion of poison exons containing in-frame stop codons is a mechanism that can be used to attenuate gene expression. Poison exon have been implicated in cancer, but how they operate within the context of normal development and physiology is poorly understood. Several ...
ORGANISM(S): Mus musculus 
2024-12-19 | GSE235084 | GEO
OtherAn essential role for the ultra-conserved poison exon of Tra2b in fertility in mice (iCLIP-seq)
Alternative splicing-induced inclusion of poison exons containing in-frame stop codons is a mechanism that can be used to attenuate gene expression. Poison exon have been implicated in cancer, but how they operate within the context of normal development and physiology is poorly understood. Several ...
ORGANISM(S): Mus musculus 
2024-12-19 | GSE235083 | GEO
ProteomicsAntisense oligonucleotide-mediated inclusion of the TRA2β ultraconserved poison exon induces the expression of a lncRNA with anti-tumor effects
Dysregulated expression of oncogenic splicing factors (SFs) occurs in human tumors in part through alterations in splicing of poison exons (PE), highly conserved exons that trigger RNA degradation. TRA2β is one such SF that undergoes PE suppression in tumor cells. Therefore, manipulation of TRA2β-PE...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD042941 | Pride
Antisense oligonucleotide  poison exon  splicing factors  sr protein  tra2-beta  alternative rna splicing  breast cancer  splicing factor  triple negative breast cancer. rna-binding proteins  patient-derived xenograft  organoid  rna pulldown  mass spectrometry 
TranscriptomicsA portable poison exon for small molecule control of mammalian gene expression
The ability to precisely control gene expression using small molecule drugs is a valuable tool in research and has significant therapeutic potential. However, existing systems are often limited by the toxicity of the drugs and the need to alter gene sequences or endogenous regulatory elements. Here,...
ORGANISM(S): Homo sapiens 
2025-09-08 | GSE303174 | GEO
GenomicsSam68 stimulates Theta-Mediated End-Joining by suppressing poison exon inclusion in Polq mRNA
Sam68 stimulates Theta-Mediated End-Joining by suppressing poison exon inclusion in Polq mRNA
PRJNA1438054 | ENA
UnknownAn autoregulatory poison exon in Smndc1 is conserved across kingdoms and influences organism growth.
Not available
S-EPMC11357089 | biostudies-literature
UnknownASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo.
Not available
S-EPMC10165353 | biostudies-literature
UnknownHNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.
Not available
S-EPMC10350819 | biostudies-literature
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